| 顺铂纳米炭混悬剂的制备及体外释药性质 |
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| 引用本文： | 徐松琳,王东凯,高斐,刘莱,徐飒.顺铂纳米炭混悬剂的制备及体外释药性质[J].中国医药工业杂志,2005,36(11):685-687. |
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| 作者姓名： | 徐松琳 王东凯 高斐 刘莱 徐飒 |
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| 作者单位： | 1. 沈阳药科大学药学院药剂系
2. 沈阳沃森药物研究所,辽宁,沈阳,110016 |
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| 摘 要： | 制备了顺铂纳米炭混悬剂并对其吸附特征和体外释药性质进行了考察.结果表明纳米炭对顺铂的吸附力强,该制剂体外释药0～10h符合零级释药模型,10～24h以一级模型释药.
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| 关 键 词： | 顺铂 纳米炭 吸附 |
| 文章编号： | 1001-8255（2005）11-0685-03 |
| 收稿时间： | 2004-09-10 |
| 修稿时间： | 2004-09-10 |
Preparation and in vitro Release of Nano-carbon Suspension Containing Cisplatin |
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| Authors: | XU Song-Lin WANG Dong-Kai GAO Fei LIU Lai XU Sa |
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| Institution: | 1. Dept. of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University; 2. Shenyan g Watson Pharmaceutical Institute, Shenyang 110016 |
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| Abstract: | The cisplatin adsorbed nano-carbon suspension was prepared. Its character of adsorption and the drugrelease in vitro was studied. The results showed that nano-carbon had a strong adsorption of cisplatin. The drug releasepattern from 0 - 10h and 10 - 24h were in accord with the zero kinetics and the first kinetics, respectively. |
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| Keywords: | cisplatin nano-carbon adsorption |
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