| 雌激素膜受体非基因组效应的研究进展 |
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| 引用本文： | 朱彤,王韫秀,顾兆伟,聂宏光,郝丽英. 雌激素膜受体非基因组效应的研究进展[J]. 实用药物与临床, 2007, 10(4): 233-235 |
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| 作者姓名： | 朱彤 王韫秀 顾兆伟 聂宏光 郝丽英 |
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| 作者单位： | 东北大学过程装备与环境工程研究所,沈阳,110004;中国医科大学附属盛京医院,沈阳,110004;中国医科大学药学院,沈阳,110001 |
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| 基金项目： | 国家自然科学基金资助项目（30671726） |
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| 摘 要： | 雌激素受体分布于哺乳动物的许多组织中,介导了大部分已知的雌激素效应。细胞膜存在雌激素受体的非基因组效应。膜受体非基因组效应参与骨骼、神经和血管及凋亡等调节作用。笔者就雌激素膜受体介导的非基因组效应进行综述。
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| 关 键 词： | 雌激素膜受体 信号通路 非基因组效应 |
| 修稿时间： | 2007-05-22 |
Research advance of non-genomic effects of membrane estrogen receptors |
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| ZHU Tong, WANG Yun-xiu, GU Zhao- wei,et al.. Research advance of non-genomic effects of membrane estrogen receptors[J]. Practical Pharmacy and Clinical Remedies, 2007, 10(4): 233-235 |
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| Authors: | ZHU Tong WANG Yun-xiu GU Zhao- wei et al. |
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| Affiliation: | 1. Process Equipment and Environmental Engineering Institute, Northeastern University, Shenyang 110004, China;2. Shengjing Hospital of China Medical University, Shenyang 110004, China;3. School of Pharmaceutical Science, China Medical University, Shenyang 110001, China |
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| Abstract: | Estrogen receptors are located in many tissues of mammals, which mediate a majority of estrogenic effects. The modulatory actions of non-genomic effects are related to skeleton, nerve system, blood vessel, apoptosis and others. The author makes a summary including membrane estrogen receptor-mediated non-genomic effects and the signal pathways involved. |
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| Keywords: | Estrogen Membrane receptor Signal pathway Non-genomic effect |
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