红细胞生成素水平与风湿免疫系统疾病并贫血患者的相关性研究

目的 研究风湿免疫系统疾病相关性贫血血清红细胞生成素水平,以了解风湿免疫系统疾病贫血患者对红细胞生成素的反应.方法 应用酶联免疫吸附方法分别检测风湿免疫系统疾病患者、肿瘤性贫血、缺铁性贫血(IDA)和正常人群血清红细胞生成素水平.风湿免疫系统疾病患者共52例,包括系统性红斑狼疮(SLE)24例,类风湿关节炎17例,干燥综合征8例,大动脉炎1例,Werger's肉芽肿1例,巨细胞动脉炎1例.所有病例均来自本院风湿免疫科、血液科和肿瘤科.正常人群来自于本院学生.入选时,有严重的肝肾功能异常、血小扳低于50×109/L、慢性失血者或合并自身免疫性溶血性贫血(Coombs试验阳性)被排除.同时还检测了血常规、网织红细胞计数、乳酸脱氢酶(LDH)、肝肾功能等指标.结果 风湿免疫系统疾病贫血组、肿瘤贫血组和缺铁性贫血组患者的血常规、网织红细胞计数、LDH和肝肾功能指标差异无统计学意义(P>0.05).肿瘤贫血组及风湿免疫系统疾病贫血组血清EPO水平明显低于缺铁性贫血组(P<0.05).结论 风湿免疫系统疾病贫血患者的贫血可能与红细胞生成素的分泌降低有关,红细胞生成素治疗可能对这些患者有益.

A Research about the serum level of erythropoiet in the anaemia patients with rheumaimmune systemic diseases

Objective To investigate whether the patients with rheumaimmune systemic diseases combining hypohemia have a low reaction to Erythropoietin(EPO).Methods The serum level of Erythropoietin(EPO) was tested respectively in the patients with Rheumaimmune systemic diseases and those who had tumorous anaemia.Also it was determined in the group of IDA patients.There were 52 patients in the Rheumaimmune systemic diseases group,including 24 patients with systemic lupus erythematosus,17 patients of rheumatoid arthriti...