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Minimally invasive colorectal resection is associated with a rapid and sustained decrease in plasma levels of epidermal growth factor (EGF) in the colon cancer setting |
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| Authors: | Michael J. Grieco H. M. C. Shantha Kumara Raymond Baxter Nadav Dujovny Matthew F. Kalady Vesna Cekic Martin Luchtefeld Richard L. Whelan |
| Affiliation: | (1) Division of Colon and Rectal Surgery, Department of Surgery, St Luke’s-Roosevelt Hospital Center, Suite 7B, 425 West 59th Street, New York, NY 10019, USA;(2) Division of Colon and Rectal Surgery, Ferguson Clinic, 4100 Lake Drive SE, Suite 205, Grand Rapids, MI 49546, USA;(3) Department of Colorectal Surgery, Digestive Disease Institute, 9500 Euclid Avenue, A 30, Cleveland, OH 44195, USA;(4) Section of Colon and Rectal Surgery, Department of Surgery, New York-Presbyterian Hospital, Columbia University, 177 Fort Washington Avenue, New York, NY 10032, USA; |
| Abstract: | BackgroundEpidermal growth factor (EGF) stimulates tumor growth directly via tumor cell EGF receptors or indirectly via its proangiogenic effects. This study’s purpose was to determine the impact of minimally invasive colorectal resection (MICR) on postoperative (postop) plasma EGF levels in the colorectal cancer (CRC) and benign disease settings and to see if preoperative (PreOp) EGF levels are altered in cancer patients. |
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