2011—2013年南通大学附属东台医院质子泵抑制剂应用分析

目的：了解南通大学附属东台医院（以下简称“我院”）质子泵抑制剂（PPI）使用情况，为临床合理用药及科学管理提供参考依据。方法：从医院信息系统（HIS）中提取2011—2013年我院质子泵抑制剂的品种、销售量、销售金额、用药频度（DDDs）、限定日费用（DDC）等数据，进行回顾性统计、分析。结果：2011-2012年我院PPI的总DDDs及总销售金额呈增长趋势，2012-2013呈负增长，DDDs及销售金额排序前3位的药品分别是奥美拉唑、兰索拉唑、泮托拉唑；2013年注射用PPI的DDDs及销售金额所占比重较高；各药的DDC呈平稳趋势。结论：我院PPI临床使用广泛，存在无适应证使用、盲目预防性应用、偏爱使用注射剂型等不合理现象，需进一步加强和完善PPI临床应用与管理的制度建设，把PPI临床应用逐步转入制度化、规范化、常规化的管理轨道，形成长效工作机制，促进医院PPI临床应用与管理水平的持续改进。

Application of Proton Pump Inhibitors in Dongtai Hospital Affiliated to Nantong University During 2011-2013

OBJECTIVE：To evaluate the application of proton pump inhibitors （PPI） in Dongtai Hospital Affiliated to Nantong University（ ＂our hospital＂）so as to provide reference for clinical rational use and scientific management of PPI. METHODS： The application data of PPIs in our hospital from 211 to 2013 including varieties, consumption amount and consumption sum, DDDs and defined daily cost （DDC） retrieved from hospital information system （HIS） were analyzed statistically. RESULTS ： The total DDDs and total consumption sum of PPI in our hospital showed upward trend from 2011 to 2012 yet negative growth from 2012 to 2013. Omeprazole, lansoprazole and pantoprazole were ranked among the top three on DDDs list ; the PPI for injection in 2013 took a great proportion in both DDDs and consumption sum. The DDC was stable for each PPI. CONCLUSIONS ： PPI had extensive clinical use in our hospital. Irrational phenomena such as use of PPI in the absence of indications, blindly preventive use, preference for the use of PPI for injection were noted, thus the construction of system regarding clinical use and management of PPI needs to be strengthened and improved to achieve institutionalized, standardized and normalized management on clinical use of PPI and form long-term working mechanism to facilitate the continuous improvement in clinical application and management of PPI.