Lambert-Eaton肌无力综合征10例临床分析

目的 探讨Lambert-Eaton肌无力综合征(Lambert-Eaton myasthenic syndrome, LEMS)的临床特点.方法对2001年3月-2011年3月诊治的10例LEMS的临床资料进行回顾性分析.结果 本组癌性LEMS 9例,临床表现为双下肢无力,体征为双下肢或双上肢力弱、双下肢腱反射减弱或消失.重复神经电刺激均示低频衰减16%~38%,高频递增152%~726%.结论 对以双下肢无力就诊的重症肌无力,应常规检查高频重复电刺激,确诊LEMS后应行常规检查和随访以早期发现肿瘤.

Clinical Analysis of 10 Patients with Lambert-Eaton Myasthenic Syndrome

Objective To investigate the clinical features of Lambert-Eaton myasthenia syndrome （LEMS）. Methods The clinical data of 10 patients with LEMS during March 2001 and March 2011 were retrospectively analyzed. Results The clinical manifestations of 9 patients with neoplasm LEMS were weakness in lower limbs, and the physical signs presented as weakness in two lower or upper limbs, and the weakness or disappearance of tendon reflex in two lower limbs. When the respective nerve stimulation （RNS） at low rate was applied, the range of the decrement in the com- pound motor action potential was from 16% -38% , while the range of increment was from 152% -726% at high rate. Con- clusion Patients with weakness in two lower limbs should be checked with RNS for LEMS at high rate. The patients diagnosed as having LEMS should be checked routinely and be followed up in order to earlier find neoplasm.