| 不同基因型慢性乙型肝炎病人对拉米呋定应答反应的初步观察 |
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| 引用本文： | 李朝霞,施云珍,宋亚军,杜素萍,厉景南,陈翔. 不同基因型慢性乙型肝炎病人对拉米呋定应答反应的初步观察[J]. 上海预防医学, 2004, 16(2): 67-68 |
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| 作者姓名： | 李朝霞 施云珍 宋亚军 杜素萍 厉景南 陈翔 |
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| 作者单位： | 浙江省东阳市人民医院,浙江,东阳,321000;浙江省东阳市人民医院,浙江,东阳,321000;浙江省东阳市人民医院,浙江,东阳,321000;浙江省东阳市人民医院,浙江,东阳,321000;浙江省东阳市人民医院,浙江,东阳,321000;浙江省东阳市人民医院,浙江,东阳,321000 |
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| 摘 要： | [目的 ] 观察拉米呋定治疗B、C基因型慢性乙型肝炎病人的临床疗效。 [方法 ] 3 5例B型慢性乙型肝炎病人及 18例C型慢性乙型肝炎病人同时给予拉米呋定 10 0mg ,每天 1次 ,疗程 1年 ,观察血清病毒学指标、肝功能变化及药物不良反应。 [结果 ] B型慢性乙型肝炎病人治疗后HBV -DNA阴转率、ALT复常率均显著高于C型慢性乙型肝炎病人 ,差异均有显著性 (P <0 .0 5 )。 [结论 ] 拉米呋定对B基因型的慢性乙型肝炎病人的临床疗效高于C基因型慢性乙型肝炎病人。拉米呋定用于治疗有病毒复制的慢性乙型肝炎病人安全有效
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| 关 键 词： | 基因型 拉米呋定 慢性乙型肝炎 |
| 文章编号： | 1004-9231(2004)02-0067-02 |
| 修稿时间： | 2003-12-10 |
Preliminary observation on clinical effect of lamivudine in chronic hepatitis B patients of different genotypes |
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| LI Zhao-xia,SHI Yun-zheni,SONG Ya-jun,DU Su-ping,LI Jing-nan,CHEN Xiang.. Preliminary observation on clinical effect of lamivudine in chronic hepatitis B patients of different genotypes[J]. Shanghai Journal of Preventive Medicine, 2004, 16(2): 67-68 |
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| Authors: | LI Zhao-xia SHI Yun-zheni SONG Ya-jun DU Su-ping LI Jing-nan CHEN Xiang. |
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| Affiliation: | Zhejiang province DongYang people's hospital. Zhejiang 321000 |
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| Abstract: | Objective] To observe the clinical effect of lamivudine to type B and type C of chronic HBV patients. [Methods] Lamivudine 100mg per day for one year were given to 35 cases type B HBV patients and 18 cases type C HBV patients. The virus index in serum, the change of the function of liver and the adverse effects of the drug were observed. [Results] After treatment, the rate of detection of HBV turned from positive to negative and rate of ALT turned normal between the two groups obviously differed(P<0.05). [Conclusion] The clinical effect of lamivudine in genotype B of the chronic HBV patients is higher than that of the genotype C ones. Using lamivudine to treat chronic HBV patients with copy of virus is effective. |
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| Keywords: | Genotype Lamivudine Chronic hepatits B |
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