| 超声靶向破坏微泡技术的应用进展 |
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| 引用本文： | 陈智毅,谢明星. 超声靶向破坏微泡技术的应用进展[J]. 中国医学影像技术, 2010, 26(9): 1790-1792 |
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| 作者姓名： | 陈智毅 谢明星 |
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| 作者单位： | 1. 广州医学院第三附属医院医学超声科,广东,广州,510150
2. 华中科技大学同济医学院 |
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| 基金项目： | 广东省医学科研基金立项课题 |
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| 摘 要： | 随着分子生物学及生物技术的迅速发展,近年来基因治疗的基础研究与应用得到了长足进步。超声靶向破坏微泡(UTMD)是一种靶向、高效、有广阔应用前景的非病毒基因输送技术,其通过诱发细胞膜声孔作用,增加膜通透性,进而有效促进大分子物质的胞内传输,且可避免其他基因传输方法的不良反应。本文对UTMD介导基因或药物传递的应用领域予以综述。
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| 关 键 词： | 超声检查 微泡 基因转移技术 基因治疗 |
| 收稿时间： | 2010-02-22 |
| 修稿时间： | 2010-05-09 |
Application progress of ultrasound-targeted microbubble destruction |
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| CHEN Zhi-yi and XIE Ming-xing. Application progress of ultrasound-targeted microbubble destruction[J]. Chinese Journal of Medical Imaging Technology, 2010, 26(9): 1790-1792 |
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| Authors: | CHEN Zhi-yi and XIE Ming-xing |
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| Affiliation: | Department of Medical Ultrasound, the Third Affiliated Hospital of Guangzhou Medical College, Guangzhou 510150, China;Department of Ultrasound, Union Hospital of Tongji Medical College of Huazhong University of Science & Technology, Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, China |
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| Abstract: | With rapid development of techniques in molecular biology, the progress of gene therapy which is mainly dependent on the development of the methods of gene delivery has promoted. Among non-viral techniques, ultrasound-targeted microbubble destruction (UTMD) is considered as a new method with fewer side effect for organ-specific gene delivery in vitro and in vivo targeting delivery, which can stimulate the micromoleculer transferring into cells efficiently and lay a foundation for cancer gene therapy. The application fields of UTMD mediated gene or drug delivery was reviewed in this article. |
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| Keywords: | Ultrasonography Microbubble Gene transfer techniques Gene therapy |
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