| THE CHARACTERISTICS OF LAMININ RECEPTOR ISOLATED FROM MURINE LUNG LEWIS CARCINOMA |
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| 引用本文： | 张青云,周柔丽. THE CHARACTERISTICS OF LAMININ RECEPTOR ISOLATED FROM MURINE LUNG LEWIS CARCINOMA[J]. 中国癌症研究, 1993, 5(2): 89-93. DOI: 10.1007/BF02997598 |
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| 作者姓名： | 张青云 周柔丽 |
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| 作者单位： | Present address- Beijing Institute for Cancer Research，Beijing 100034，Department of Cell Biology，Beijing Medical University，Beijing 100083 |
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| 摘 要： | Laminin receptor(LN-R, Mr=70,000) isolated from murine Lewis lung carcinoma was shown to be a single band on SDS-PAGE (Sodium Dodecyl Sulfate-Polyacrylamide gel electrophoresis) after reduction. The present study Indicates that LN-R was a kind of glycoproteins by periodic add Schiff staining. It's pI was 4. 93. LN-R preperation was associated with phospholipid and neutral glycolipid by TLC (thin layer chromatography) or HPTLC (high performance thin layer chromtography) of chloroform-methanol extracts of LN-R, respectively, but without acidic glycolipid. Binding of LN-R with its ligand, Lamlnin, depended on the presence of Ca , Mg . LN-R may bind to actin.
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The characteristics of Laminin receptor isolated from murine lung Lewis carcinoma |
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| Qingyun Zhang,Rouli Zhou. The characteristics of Laminin receptor isolated from murine lung Lewis carcinoma[J]. Chinese Journal of Cancer Research, 1993, 5(2): 89-93. DOI: 10.1007/BF02997598 |
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| Authors: | Qingyun Zhang Rouli Zhou |
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| Affiliation: | Zhang Qingyun Zhou RouliDepartment of Cell Biology,Beijing Medical University,Beijing 100083 Present address- Beijing Institute for Cancer Research,Beijing 100034 |
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| Abstract: | Laminin receptor(LN-R, Mr=70,000) isolated from murine Lewis lung carcinoma was shown to be a single band on SDS-PAGE (Sodium Dodecyl Sulfate-Polyacrylamide gel electrophoresis) after reduction. The present study Indicates that LN-R was a kind of glycoproteins by periodic add Schiff staining. It's pI was 4. 93. LN-R preperation was associated with phospholipid and neutral glycolipid by TLC (thin layer chromatography) or HPTLC (high performance thin layer chromtography) of chloroform-methanol extracts of LN-R, respectively, but without acidic glycolipid. Binding of LN-R with its ligand, Lamlnin, depended on the presence of Ca , Mg . LN-R may bind to actin. |
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| Keywords: | Laminin Laminin receptor Glycoprotein Lewis lung carcinoma |
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