| 假轮枝链霉菌 Streptomyces pseudoverticillus产生的Elaiophylin类新细胞周期抑制剂及细胞凋亡诱导剂Ⅱ.化学结构及生物活性(英文) |
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| 引用本文： | 崔承彬,王浩,韩冰,蔡兵,骆爱群,宋幼新,周培瑾. 假轮枝链霉菌 Streptomyces pseudoverticillus产生的Elaiophylin类新细胞周期抑制剂及细胞凋亡诱导剂Ⅱ.化学结构及生物活性(英文)[J]. 中国抗生素杂志, 2001, 0(3) |
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| 作者姓名： | 崔承彬 王浩 韩冰 蔡兵 骆爱群 宋幼新 周培瑾 |
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| 作者单位： | 北京生物医药研究所!北京100091(崔承彬，韩冰，蔡兵)，中国科学院微生物研究所!北京100080(王浩，骆爱群，宋幼新，周培瑾) |
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| 基金项目： | 国家杰出青年基金 No.3982 51 2 6，国家重点基础研究发展规划项目 (973项目 )基金 No.1 9980 51 1 1 3资助项目 |
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| 摘 要： | 通过 X-线晶体结构解析及光谱学数据分析 ,将从假轮枝链霉菌 Streptomyces pseudoverticillus发酵物中分得的三个elaiophylin类化合物分别鉴定为 elaiophylin(1)、11- O- monomethylelaiophylin(2 )和 efomycin G(3)。化合物 1～ 3在高浓度区均有很强的细胞毒作用 ,而在低浓度区均呈很好的细胞周期抑制和细胞凋亡诱导活性 ,系 elaiophylin类新的细胞周期抑制剂及细胞凋亡诱导剂
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| 关 键 词： | 假轮枝链霉菌 Elaiophylin 11-O-monomethylelaiophylin Efomycin G 细胞周期抑制剂 细胞凋亡诱导剂 X-线晶体结构 |
Elaiophylins, new cell cycle inhibitors and apoptosis inducers, produced by Streptomyces pseudoverticillus II. Structures and biological properties |
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| Cui Cheng bin ,Wang Hao ,Han Bing ,Cai Bing ,Luo Ai qun ,Song You xin and Zhou Pei jin. Elaiophylins, new cell cycle inhibitors and apoptosis inducers, produced by Streptomyces pseudoverticillus II. Structures and biological properties[J]. Chinese Journal of Antibiotics, 2001, 0(3) |
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| Authors: | Cui Cheng bin Wang Hao Han Bing Cai Bing Luo Ai qun Song You xin Zhou Pei jin |
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| Affiliation: | Cui Cheng bin 1,Wang Hao 2,Han Bing 1,Cai Bing 1,Luo Ai qun 2,Song You xin 2 and Zhou Pei jin 2 |
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| Abstract: | Three elaiophylins isolated from the culture broth of Streptomyces pseudoverticillus YN17707 were identified as elaiophylin (1), 11 O monomethylelaiophylin (2), and efomycin G (3), by X ray crystal structure analysis and spectroscopy. The elaiophylins 1~3 showed a strong cytotoxicity at higher concentrations and also showed the cell cycle inhibitory and apoptosis inducing activities at lower concentrations and they were regarded as new cell cycle inhibitors and apoptosis inducers. |
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| Keywords: | Streptomyces pseudoverticillus Elaiophylin 11 O Monomethylelaiophylin Efomycin G Cell cycle inhibitor Apoptosis inducer X Ray crystal structure |
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