| 婴幼儿亚临床甲状腺功能减退症诊断治疗和随访——附107例临床分析 |
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| 引用本文： | 周雪莲,毛华庆,杨茹莱,陈肖肖,陈汉云,施玉华,曹莉佩,赵正言.婴幼儿亚临床甲状腺功能减退症诊断治疗和随访——附107例临床分析[J].中华内分泌代谢杂志,2008,24(6). |
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| 作者姓名： | 周雪莲 毛华庆 杨茹莱 陈肖肖 陈汉云 施玉华 曹莉佩 赵正言 |
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| 作者单位： | 浙江大学医学院附属儿童医院,杭州,310003 |
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| 基金项目： | 浙江省卫生厅资助项目 |
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| 摘 要： | 107例患儿经1～8次检查后血清TSH值均>20 mIU/L,血FT4、TT4值在正常低值范围,治疗4周后复查,血TSH明显下降,血FT4、TT4值较前升高(均P<0.01).甲状腺B超检查7例(6.54%)显示甲状腺发育不良,7例(6.54%)甲状腺肿大血流丰富,93例(86.91%)位置大小形态无异常.左旋甲状腺素初始剂量以3～4 μg·kg-1·d-1为宜.
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| 关 键 词： | 甲状腺功能减退症 婴幼儿 治疗 随访研究 |
Diagnosis, therapy and follow-up in infants with subclincal hypothyroidism--A clinical analysis of 107 cases |
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| ZHOU Xue-lian,MAO Hua-qing,YANG Ru-lai,CHEN Xiao-xiao,CHEN Han-yun,SHI Yu-hua,CAO Li-pei,ZHAO Zheng-yan.Diagnosis, therapy and follow-up in infants with subclincal hypothyroidism--A clinical analysis of 107 cases[J].Chinese Journal of Endocrinology and Metabolism,2008,24(6). |
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| Authors: | ZHOU Xue-lian MAO Hua-qing YANG Ru-lai CHEN Xiao-xiao CHEN Han-yun SHI Yu-hua CAO Li-pei ZHAO Zheng-yan |
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| Abstract: | The serum TSH levels of 107 infants with subclinical hypothyroidism (SH) were > 20 mIU/L after 1-8 check-up, along with FT4, TT4, within low normal range. After given small dosage L-T4, for 4 weeks, blood TSH level obviously descended while FT4, TT4, ascended (all P <0.01). Seven cases of thyroid hypogenesis and 7 strumas were found by ultrasonography. It seems appropriate to use dosage of 3-4 μg·kg·-1·d-1 L-T4 in treating SH. |
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| Keywords: | Hypothyroidism Infants Therapy Follow-up studies |
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