Increased expression of the CD45RO (memory) antigen on T cells in HIV-infected children. |
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| Authors: | K S Froebel K V Doherty J A Whitelaw R A Hague J Y Mok A G Bird |
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| Affiliation: | HIV Immunology Unit, University Department of Medicine, Edinburgh, Scotland, UK. |
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| Abstract: | Expression of the CD45RO putative memory cell antigen on CD4 (helper) and CD8 (cytotoxic/suppressor) lymphocytes of children born to HIV-infected women was investigated using the UCHL1 antibody. Significantly raised numbers of CD45RO+ CD8 lymphocytes were found in all nine of the infected children compared with uninfected and control children. Expression of CD45RO on CD4 lymphocytes was variable; absolute numbers were not increased, although the percentage was increased in four out of nine infected children. All the infected children except two (who had comparatively low numbers of CD45RO+ CD8 cells) were clinically well, which suggests that an increase in CD45RO+ CD8 cells may be indicative of a functionally active immune response against HIV. |
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