| 导向综合治疗对肝癌耐药基因表达的影响 |
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| 引用本文： | 汤文英,汤钊猷,刘康达,邹合强,鲍卫华.导向综合治疗对肝癌耐药基因表达的影响[J].复旦学报(医学版),1995(2). |
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| 作者姓名： | 汤文英 汤钊猷 刘康达 邹合强 鲍卫华 |
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| 作者单位： | 上海医科大学肝癌研究所 |
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| 基金项目： | 中山医院中青年研究基金资助 |
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| 摘 要： | 用ＡＢＣ免疫组织化学方法（简称组化）对９２例肝细胞肝癌（ＨＣＣ）标本进行了耐 药基因产物 Ｐ－ＧＰ的检测。结果：术前未治疗的 ７６例 ＨＣＣ中，癌与癌周肝 Ｐ－ＧＰ组化染色 阳性率分别为６０．５％（４６／７６）与６９．７％（５３／７６）；由导向综合治疗后切除的１６例标本中其癌 与癌周肝分别为３１．２％（５／１６）与７８．３％（１１／１５）。表明经导向综合治疗后ＨＣＣ中Ｐ－ＧＰ的 表达显著低于来治疗组（Ｐ＜０．０５）。提示导向综合治疗有助于克服ＨＣＣ耐药。
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| 关 键 词： | 肝细胞肝癌 耐药基因 P-GP 免疫组织化学 导向综合治疗 |
EXPRESSION OF MULTIDRUG RESISTANCE GENE AFTER MULTIMODALITY TARGETING TREATMENT OF HEPATOCELLULAR CARCINOMA |
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| Tang Wenying,Tang Zhaoyou,Liu Kangda,Zou Heqiang,Bao Weihua.EXPRESSION OF MULTIDRUG RESISTANCE GENE AFTER MULTIMODALITY TARGETING TREATMENT OF HEPATOCELLULAR CARCINOMA[J].Fudan University Journal of Medical Sciences,1995(2). |
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| Authors: | Tang Wenying Tang Zhaoyou Liu Kangda Zou Heqiang Bao Weihua |
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| Abstract: | A total of 96 specimens of hepatocellular carcinoma (HCC) and its surrounding liver tissues were studied to assess the expression multidrug resistance (mdr) gene product P-glycoprotein (P-GP) in HCC. P-GP was evaluated by an immunopexoxidase detection system. Results: In 76 untreated cases, P-GP was detected in 60.5%(46/76) of HCC, and in 69.7%(53/76) of surrounding liver tissues. In multimodality targeting treatment group (n= 16), expression of P-GP was observed in only 31.2%(5/16) of HCC and in 73.3%(11/15) of surrounding liver tissues. Expresaion of P-CP in multimodality targeting treatment group statistically lower then thet of untreated group (P<0.05). The results indicate that by multimodality targeting treatment, such as radioimmunotherapy, might change multidrug resistance of HCC. |
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| Keywords: | hepatocellular carcinoma multidrug resistance P-GP im- munochemistry multimodality targeting treatment |
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