Noninterference of isosulfan blue on estrogen-receptor activity |
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Authors: | Hirsch JI; Banks WL Jr; Sullivan JS; Horsley JS d |
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Institution: | Department of Radiology, Massey Cancer Center, Richmond, VA. |
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Abstract: | Because a 1% sterile solution of methylene blue used for occult breast tumor localization has been shown to interfere with the estrogen-receptor protein (ERP) binding-capacity assay, isosulfan blue in a 1% injection was studied as a potential alternate stain. Cytosols derived from ERP-positive lyophilized powders and human breast tissue were evaluated with and without varying levels of treatment with isosulfan blue. No modification of the ERP-specific binding capacity was found with this stain. The use of isosulfan blue for localization of occult breast tumor is suggested when an ERP binding capacity assay is anticipated. |
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