Decreased Bone Mass and Strength in Ovariectomized Cynomolgus Monkeys (Macaca fascicularis) |
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Authors: | C P Jerome C H Turner C J Lees |
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Institution: | (1) Department of Comparative Medicine, Bowman Gray School of Medicine, Medical Center Boulevard Winston-Salem, North Carolina 27157-1040, USA, US;(2) Department of Orthopaedic Surgery, Indiana University, Indianapolis, Indiana 46202-5111, USA, US |
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Abstract: | Agents for prevention or treatment of osteoporosis must now be tested in a large animal species that exhibits bone remodeling.
Ovariectomized, nonhuman primates provide one such model, and they consistently develop osteopenia accompanied by high bone
turnover rates. The goal of this study was to further characterize this model, and particularly to determine the effect of
ovariectomy on bone strength in vertebrae and femoral necks. Longitudinal evaluations of spinal bone mass and serum markers
of bone turnover were performed in 19 sham-ovariectomized (SHAM) and 18 ovariectomized (OVX), domestically reared cynomolgus
monkeys, aged >9 years. OVX monkeys lost bone relative to both baseline values and SHAM controls. Serum markers of bone turnover
were increased by OVX. After 72 weeks, both vertebral bone compressive strength and femoral neck breaking strength were significantly
decreased in OVX animals compared with SHAM. Ovariectomized cynomolgus monkeys, like postmenopausal women, develop accelerated
bone loss, increased bone turnover, and reduced bone strength, and provide a suitable large animal model for efficacy studies
with agents for prevention or treatment of osteoporosis.
Received: 24 June 1996 / Accepted: 3 September 1996 |
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Keywords: | : Osteopenia — Bone density — Nonhuman primates — Osteoporosis — Bone biomechanics |
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