Treatment options for a patient experiencing pruritic rash associated with transdermal testosterone: a review of the literature. |
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| Authors: | N J McGriff G Csako M Kabbani L Diep G P Chrousos F Pucino |
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| Institution: | Pharmacy Department, Warren G. Magnuson Clinical Center, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, USA. n.mcgrif@usip.edu |
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| Abstract: | A 22-year-old man with hypogonadotropic hypogonadism was receiving monthly intramuscular injections of testosterone replacement therapy. The patient refused to self-administer the injections because of discomfort, so the therapy was switched to testosterone patches. He experienced a pruritic, macular, erythematous rash underneath the reservoir area of two different transdermal formulations, which did not improve after pretreatment with topical corticosteroids. Eventually, he tolerated application of a testosterone gel and his serum testosterone levels returned to normal after 1 month of therapy. Commercially available and investigational testosterone products and therapeutic monitoring guidelines for androgen replacement are reviewed. |
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