小剂量支气管动脉灌注化疗联合局部放射治疗高龄非小细胞肺癌的临床观察

目的探讨小剂量支气管动脉灌注化疗联合局部放射治疗高龄非小细胞肺癌（NSCLC）的临床疗效。方法120例高龄NSCLC患者按病理类型随机分为2个组：观察组60例，采用小剂量支气管动脉灌注化疗2次，同时给予局部放射治疗；对照组60例，仅采用局部放射治疗。结果两组中鳞癌完全缓解（CR）＋部分缓解（PR）率分别为86．7％（26／30）、60．0％（18／30）；2年生存率分别46．7％（14／30）、36．7％（6／30）；两组中腺癌CR＋PR率分别为70．0％（21／30）、30．0％（9／30）；2年生存率分别为30．O％（9／30）、10．0％（3／30）。两组患者CR＋PR率均有显著差异（P〈0．05）。两组患者1年生存率、2年生存率毒副作用均无显著差异（P〉0．05）。结论小剂量支气管动脉灌注化疗加局部放射治疗，对于高龄NSCLC患者是一种有效的治疗方法，可提高患者的生活质量，延长患者的生存时间，同时也为高龄NSCLC提供了一种新的治疗途径。

Clinical observation of small doses of chemotherapy of bronchial arterial infusion and partial radiotherapy in the treatment of elderly patients with non-small cell lung cancer

Objective To study clinical effect of small doses of chemotherapy of bronchial arterial infusion and partial radiotherapy in the treatment of patients elderly non-small cell lung cancer （NSCLC）. Methods 120 cases of elderly NSCLC patients were randomly divided into two groups according to pathological type. The observation group （60 cases） was treated by small doses bronchial artery infusion chemotherapy, while local radiotherapy. The control group （60 cases） was treated by localized radiation therapy was given. Results CR ＋ PR rate of patients with squamous cell carcinoma in two groups were 86.7% （26/30）, 60.0% （18/30） respectively. Two-year survival rate were 46.7 % （ 14/30）, 36.7 % （6/30） respectively. CR ＋ PR rate of patients with adenocarcinoma in two groups were 70.0% （21/30）, 30.0% （9/30） respectively. Two-year survival rate were 30.0% （9/30）, 10.0% （3/30） respectively. CR ＋ PR rate in two groups were significant difference（P 〈 0.05）. One-year survival rate, two-year survival rate and side effects in the two groups were not significant different （ P 〉 0.05）. Conclusion small dose of chemotherapy of bronchial arterial infusion and partial radiotherapy is an effective treatment for elderly NSCLC patients, and can improve the life quality of the patients, and can prolong the survival time of patients, and can provide a new therapeutic approach for elderly NSCLC.