肺内磨玻璃影的分子生物学研究进展

近年来，低剂量CT广泛应用于早期肺癌的筛查，肺内磨玻璃影(ground-glass opacity，GGO)的检出率逐渐升高。多数学者认为它与早期肺腺癌密切相关，其定性诊断和早期治疗对于提高早期肺癌患者的诊断率与生存率具有重要意义。关于GGO的影像学诊断、定位方法及手术方式进展国内外已有许多报道，现重点将近年来与其分子生物学方面相关的研究进展综述如下。

Research progress of molecular biology in ground-glass opacity

With the low-dose spiral computed tomography (LDCT) widely applied in screening for earlystage lung cancers recently, positive rates of Ground-Glass Opacity (GGO) are gradually increased. Many professional researchers believe GGO has a close relationship with the early-stage lung adenocarcinoma, consequently, qualitative diagnosis and early treatment of GGO plays a significant role in improving the diagnostic and survival rates of patients with early-stage lung cancer. Since relative imaging diagnosis, location methods and surgical approaches of GGO have been reported a lot by domestic and overseas researchers, our reviews would mainly focus on the diverse research progress of molecular biology of GGO in the past several years.