| 白芍饮片HPLC指纹图谱的定量标示研究 |
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| 引用本文： | 赫炎,赵慧东,唐力英,王祝举,张启伟. 白芍饮片HPLC指纹图谱的定量标示研究[J]. 中国中药杂志, 2007, 32(12): 1161-1163 |
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| 作者姓名： | 赫炎 赵慧东 唐力英 王祝举 张启伟 |
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| 作者单位： | 1. 中国中医科学院,中医临床基础医学研究所,北京,100700
2. 中国中医科学院,中药研究所,北京,100700 |
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| 摘 要： | 目的：探讨如何应用HPLC指纹图谱的计量技术对白芍炒制过程及白芍饮片进行质量控制。方法：中试生产研制白芍饮片,HPLC,PFA(principal factor analysis)。结果：获得了较稳定的白芍饮片HPLC图谱；在不同产地和不同饮片品种图谱的10个特征峰中,通过各个峰之间的联带变化在不同饮片中的分布规律,运用PFA的信息处理技术,抽取出能反映对HPLC谱中峰群有影响的2个公共因子,其累计贡献率为64.8%,根据各峰对因子的载荷和communality筛选出的7个峰可作为主要反映图谱形状变化的目标峰群。结论：HPLC指纹图谱和PFA可用于白芍的炒制工艺过程和饮片的质量控制。
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| 关 键 词： | 白芍 色谱指纹图谱 |
| 文章编号： | 1001-5302（2007）12-1161-04 |
| 收稿时间： | 2006-03-28 |
| 修稿时间： | 2006-03-28 |
Quantititive study for chromatographic fingerprints of processed products of Paeonia lactiflora |
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| HE Yan; ZHAO hui-dong; TANG Li-ying; WANG Zhu-ju; ZHANG Qi-wei. Quantititive study for chromatographic fingerprints of processed products of Paeonia lactiflora[J]. China Journal of Chinese Materia Medica, 2007, 32(12): 1161-1163 |
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| Authors: | HE Yan ZHAO hui-dong TANG Li-ying WANG Zhu-ju ZHANG Qi-wei |
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| Affiliation: | 1. Institute of Basic Clinical Medicine, China Academy of Chinese Medical Sciences, Belling 100700, China ; 2. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Belling 100700, China |
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| Abstract: | Objective: To explore the utility of Principal Factor Analysis (PFA) in chromatographic data for quality control. Method: Chromatographic fingerprints of processed root pieces of Paeonia lactiflora were determined by HPLC, the PFA was used for data processing. Result: The quantitative differences among different growing areas and different processing batches were found with the method. Conclusion: The method could be used in quality control for monitoring between-atch products of traditional Chinese pharmaceutical process. |
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| Keywords: | PFA HPLC |
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