老年高血压肾病血小板活化分子检测的意义

目的 :评估血小板在老年高血压肾病中的活化状态及意义。方法 :利用流式细胞仪检测了 64例老年高血压肾病患者及 2 1例健康自愿者外周血小板的膜糖蛋白CD62P、CD63、CD 41和CD61的表达。结果 :老年高血压肾病组CD62P、CD63的表达较对照组显著增高 (P <0 0 0 1) ,CD41和CD61的表达与对照组比较差异无显著性(P >0 0 5 )。老年高血压肾病组CD62P、CD63的表达组间差异有显著性 (P <0 0 5 ) ,且随血压分级水平升高而递增。结论 :老年高血压肾病时血小板活化增强 ,推测其在老年高血压肾病发生发展中起重要作用。

Significance of platelet activation markers in elderly hypertensive nephropathy

Objective To evaluate detection of active platelet status in elderly hypertensive nephropathy and its significance. Methods In 64 elderly patients with hypertensive nephropathy and 21 healthy volunteers, the expression level of peripheral platelet membrane glycoproteins CD62p, CD63, CD41 and CD61 were measured by flow cytometry. Results The expression level of CD62p and CD63 on platelet in the group of hypertensive nephropathy was significantly higher than that in the healthy control group (P<0.01), however, the expression level of CD41 and CD61 on platelet in the group of hypertensive nephropathy was no significant difference as compared to the healthy control group (P>0.05). The expression level of CD62P and CD63 on platelet in patients had significant difference between groups of hypertension stage and increased in parallel with stage level. Conclusion The platelet activity increases in hypertensive nephropathy. It is suggested that activated platelets may play a major role in the development of hypertensive nephropathy.