| 应用FTIR分析技术快速鉴定中药伟哥中的西地那非 |
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| 引用本文： | 宋占军,董方霆,魏开华,梁月琴,吴胜明,赵法,杨根锁,刘炳玉,郑永红,杨松成.应用FTIR分析技术快速鉴定中药伟哥中的西地那非[J].解放军药学学报,2003,19(5):357-359. |
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| 作者姓名： | 宋占军 董方霆 魏开华 梁月琴 吴胜明 赵法 杨根锁 刘炳玉 郑永红 杨松成 |
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| 作者单位： | 国家生物医学分析中心,北京,100850 |
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| 摘 要： | 目的 对标识由加多种中草药成分组成的中药伟哥成药中，所含的西地那非成分及其来源进行了快速鉴定。方法 应用傅立叶变换红外光谱分析技术(FTIR)，测定了原药和西地那非柠檬酸盐标准品的红外光谱，并进行了红外光谱定性对比分析，对原药中提取物进行了红外光谱分析，对人工模拟配方进行了对比分析。结果 在中药伟哥成药所含的加多种中草药中未发现西地那非成分。结论 中药伟哥成药中所含的西地那非为非中草药成分来源。
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| 关 键 词： | 中药伟哥 西地那非 傅立叶变换红外光谱分析技术 西地那非柠檬酸盐 |
| 文章编号： | 1008-9926(2003)05-0357-03 |
| 修稿时间： | 2002年9月5日 |
Identification of sildenafil in the patent Chinese medicine-Traditional Chinese Viagra by FTIR |
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| SONG Zhan Jun,DONG Fang Ting,WEI Kai Hua,LIANG Yue Qin,WU Sheng Ming,ZHAO Fa,YANG Gen Suo,LIU Bin Yu,ZHENG Yong Hong,YANG Song Cheng.Identification of sildenafil in the patent Chinese medicine-Traditional Chinese Viagra by FTIR[J].Pharmaceutical Journal of Chinese People's Liberation Army,2003,19(5):357-359. |
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| Authors: | SONG Zhan Jun DONG Fang Ting WEI Kai Hua LIANG Yue Qin WU Sheng Ming ZHAO Fa YANG Gen Suo LIU Bin Yu ZHENG Yong Hong YANG Song Cheng |
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| Abstract: | Aim To identify Sildenafil and its origin in one patent Chinese medicine.Methods Traditional Chinese Viagra,composed of 20 species of Chinese herbal medicines were identified by Fourier Transformation Infrared Spectrum(FTIR).FTIR of the Chinese viagra and sildenafil citrate standard were measured and the spectrum difference has been compared.The alkaloid extracted from the original medicine was analyzed by FTIR.Results Any species did not contain sildenafil in the 20 species of Chinese herbal medicines.Conclusion The sildenafil in patent Chinese medicine is not from Chinese herbal medicine. |
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| Keywords: | Infrared spectrum Traditional Chinese Viagra Sildenafil Sildenafil citrate |
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