前列腺素E1在高氧肺损伤中的保护作用

目的：研究前列腺素El对高氧诱导的急性肺损伤是否有保护作用。方法：40只雄性SD大鼠被随机分成四组。分别予腹腔注射生理盐水或前列腺素El(PGEl)后暴露于21％O2或95％O272h，分别测定支气管肺泡灌洗液(BALF)中的总蛋白(TP)、乳酸脱氢酶(LDH)、粒细胞数及血清总蛋白，并作肺组织形态学观察。结果：PGEl腹腔注射组暴露于高氧后BALF中的TP，LDH及粒细胞数量较使用生理盐水的高氧暴露组显著下降，而血清总蛋白无显著性差异。肺组织石蜡包埋切片HE染色，光镜下观察高氧暴露组肺组织水肿。结论：高氧可诱导急性肺损伤：PGEl对高氧诱导的肺损伤有保护作用。

LUNG PROTECTIVE EFFECT OF PROSTAGLANDIN E1 IN ACUTE LUNG INJURY INDUCED BY HYPEROXIA

Objective:To determine whether prostaglandin E1 (PGE1) attenuates pulmonary oxygen toxicity.Methods:Fifty male Sprague-Danley rats were divided randomly into four groups. The animals were injected intraperitoneally with saline or PGE1 and immediately exposed to either 21%O 2 or 95%O 2 for 72 hours. Lactate dehydrogenase (LDH) activity, total protein content, and numbers of granulocytes were measured in the bronchoalveolar lavage fluid and serum.Results:LDH activity, protein content,and numbers of granulocytes was significantly decreased ( P <0.01) in these animals treated with PGE1 prior to and in exposure to hyperoxia compared with those animals exposed to hyperoxia and not treated with PGE1.Conclusions:Hyperoxia can induce acute lung injury and PGE1 can attenuate pulmonary oxygen toxicity.