| 广州地区106株淋球菌中脂蛋白分型与环丙沙星耐药相关性研究 |
| |
| 引用本文： | 龚子鉴,赖维,黄朝伟,刘敏. 广州地区106株淋球菌中脂蛋白分型与环丙沙星耐药相关性研究[J]. 岭南皮肤性病科杂志, 2011, 18(3): 148-152 |
| |
| 作者姓名： | 龚子鉴 赖维 黄朝伟 刘敏 |
| |
| 作者单位： | 1. 中山大学附属第三医院,广东,广州,510630
2. 海南省皮肤病医院,海南,海口,570206 |
| |
| 摘 要： | 目的:研究广州地区106株淋球菌中脂蛋白分型与环丙沙星耐药的相关性.方法:用糖琼脂稀释法测定淋球菌对环丙沙星的MIC值,PCR分别扩增淋球菌的gyrA、parC和脂蛋白基因并测序分析.结果:广州地区106株淋球菌对环丙沙星的耐药率为95 3%,共有19个脂蛋白亚型,最常见的亚型是17c,有49株(46 2%).对环丙沙星耐药的101株菌中,所有菌株在gyrA基因对应氨基酸的第91和95位点上均发生了突变,而parC基因随着MIC值的升高发生位点突变的概率呈上升趋势.在中低水平耐药组中,最常见的脂蛋白亚型是17c和14d,均有12株(28 6%).在高水平耐药组中,最常见的脂蛋白亚型是17c,有35株(59 3%),其次是14d,有11株(18 6%).结论:淋球菌脂蛋白亚型的分布存在地域性,与环丙沙星耐药程度高低无明显相关性.
|
| 关 键 词： | 淋病耐瑟氏菌 脂蛋白分型 环丙沙星耐药 |
Relationship between Lipoprotein Subtyping and Ciprofloxacin Resistance in 106 Neisseria Gonorrhoeae Strains in the District of Guangzhou |
| |
| GONG Zi-jian,LAI Wei,HUANG Chao-wei,LIU Min. Relationship between Lipoprotein Subtyping and Ciprofloxacin Resistance in 106 Neisseria Gonorrhoeae Strains in the District of Guangzhou[J]. Southern China Journal of Dermato-Venereology, 2011, 18(3): 148-152 |
| |
| Authors: | GONG Zi-jian LAI Wei HUANG Chao-wei LIU Min |
| |
| Affiliation: | GONG Zi-jian1,LAI Wei1,HUANG Chao-wei2,LIU Min1(Department of Dermatology and Venerology,the Third Affiliated Hospital of Sun Yat-sen University,GuangZhou 510630,China) |
| |
| Abstract: | Objective:To study the relationship between lipoprotein subtypes and ciprofloxacin resistance in 106 Neisseria gonorrhoeae strains in the district of Guangzhou. Methods:Minimal inhibitory concentrations(MIC) of ciprofloxacin were used to determine gonococci isolated by agar dilution method.The genes of gyrA,parC and lipoprotein were amplified by PCR,and then sequenced and analyzed. Results:Among the 106 strains,the resistance rate of ciprofloxacin was 95.3% with a total of 19 Lip subtypes.The most common su... |
| |
| Keywords: | Neisseria gonorrhoeae Lip subtypes Ciprofloxacin resistance |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
