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Incidence of Cancer Following Bariatric Surgery: Systematic Review and Meta-analysis
Authors:Daniela Schaan Casagrande  Daniela Dornelles Rosa  Daniel Umpierre  Roberta Aguiar Sarmento  Clarissa Garcia Rodrigues  Beatriz D. Schaan
Affiliation:1. Postgraduate Program in Medical Sciences: Endocrinology and Metabolism, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos 2350, prédio 12, 4° andar, 90035-003, Porto Alegre, RS, Brazil
2. Obesity and Metabolic Syndrome Center of Hospital S?o Lucas, Pontifícia Universidade Católica do Rio Grande do Sul (COM HSL-PUCRS), Porto Alegre, Brazil
3. Oncology Unit, Hospital Moinhos de Vento, Porto Alegre, Brazil
4. Postgraduate Program in Health Sciences: Cardiovascular Sciences, Universidade Federal do Rio Grande do Sul, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
5. Funda??o Universitária de Cardiologia, Instituto de Cardiologia do Rio Grande do Sul (IC-FUC), Porto Alegre, Brazil
6. Duke Global Health Institute (DGHI), Duke University, Durham, NC, USA
Abstract:Obesity is linked to the development of cancer. Previous studies have suggested that there is a relationship between bariatric surgery and reduced cancer risk. Data sources were from Medline, Embase, and Cochrane Library. From 951 references, 13 studies met the inclusion criteria (54,257 participants). In controlled studies, bariatric surgery was associated with a reduction in the risk of cancer. The cancer incidence density rate was 1.06 cases per 1000 person-years within the surgery groups. In the meta-regression, we found an inverse relationship between the presurgical body mass index and cancer incidence after surgery (beta coefficient ?0.2, P?
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