Spironolactone in Patients With Heart Failure,Preserved Ejection Fraction,and Worsening Renal Function |
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Authors: | Iris E. Beldhuis Peder L. Myhre Michael Bristow Brian Claggett Kevin Damman James C. Fang Jerome L. Fleg Sonja McKinlay Eldrin F. Lewis Eileen O’Meara Bertram Pitt Sanjiv J. Shah Orly Vardeny Adriaan A. Voors Marc A. Pfeffer Scott D. Solomon Akshay S. Desai |
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Affiliation: | 1. Cardiovascular Division, Brigham and Women’s Hospital, Boston, Massachusetts, USA;2. University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands;3. Division of Medicine, Akershus University Hospital, Lorenskog, Norway;4. Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA;5. University of Utah School of Medicine, Salt Lake City, Utah, USA;6. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA;7. New England Research Institutes, Watertown, Massachusetts, USA;8. Montreal Heart Institute, Montreal, Quebec, Canada;9. University of Michigan School of Medicine, Ann Arbor, Michigan, USA;10. Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA;11. Minneapolis VA Center for Care Delivery and Outcomes Research, University of Minnesota, Minneapolis, Minnesota, USA |
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Abstract: | BackgroundTreatment of heart failure with preserved ejection fraction (HFpEF) with spironolactone is associated with lower risk of heart failure hospitalization (HFH) but increased risk of worsening renal function (WRF). The prognostic implications of spironolactone-associated WRF in HFpEF patients are not well understood.ObjectivesThe purpose of this study was to investigate the association between WRF, spironolactone treatment, and clinical outcomes in patients with HFpEF.MethodsIn 1,767 patients randomized to spironolactone or placebo in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial)-Americas study, we examined the incidence of WRF (doubling of serum creatinine) by treatment assignment. Associations between incident WRF and subsequent risk for the primary study endpoint of cardiovascular (CV) death, HFH, or aborted cardiac arrest and key secondary outcomes, including CV death, HFH, and all-cause mortality according to treatment assignment, were examined in time-updated Cox proportional hazards models with an interaction term.ResultsWRF developed in 260 (14.7%) patients with higher rates in those assigned to spironolactone compared to placebo (17.8% vs. 11.6%; odds ratio: 1.66; 95% confidence interval: 1.27 to 2.17; p < 0.001). Regardless of treatment, incident WRF was associated with increased risk for the primary endpoint (hazard ratio: 2.04; 95% confidence interval: 1.52 to 2.72; p < 0.001) after multivariable adjustment. Although there was no statistical interaction between treatment assignment and WRF regarding the primary endpoint (interaction p = 0.11), spironolactone-associated WRF was associated with lower risk of CV death (interaction p = 0.003) and all-cause mortality (interaction p = 0.001) compared with placebo-associated WRF.ConclusionsAmong HFpEF patients enrolled in TOPCAT-Americas, spironolactone increased risk of WRF compared with placebo. Rates of CV death were lower with spironolactone in both patients with and without WRF. |
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Keywords: | heart failure with preserved ejection fraction spironolactone worsening renal function eGFR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0030" }," $$" :[{" #name" :" text" ," _" :" estimated glomerular filtration rate HFpEF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0040" }," $$" :[{" #name" :" text" ," _" :" heart failure with preserved ejection fraction HFrEF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" heart failure with reduced ejection fraction WRF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" worsening renal function |
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