Basal cell adenocarcinoma of the parotid gland: Comparison with basal cell adenoma for preoperative diagnosis |
| |
| Authors: | Tetsuya Terada Ryo Kawata Masaaki Higashino Yoshitaka Kurisu Hiroko Kuwabara Yoshinobu Hirose |
| |
| Affiliation: | 1. Department of Otorhinolaryngology - Head and Neck Surgery, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki 569-8686, Osaka, Japan;2. Department of Pathology, Osaka Medical College, Takatsuki, Osaka, Japan;1. Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea;2. Department of Neurology, Hallym University College of Medicine, Anyang, South Korea;3. Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea;4. Department of Laboratory Medicine, Hallym University College of Medicine, Anyang, South Korea;5. Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Dongtan, South Korea;1. Department of Otorhinolaryngology, Jikei University School of Medicine, Tokyo, Japan;2. Department of Otorhinolaryngology, Ota General Hospital, Kanagawa, Japan;1. Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan;2. Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan;3. Department of Anatomic Pathology, Tokyo Medical University School of Medicine, Tokyo, Japan;1. Department of Otolaryngology – Head and Neck Surgery, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka 569-8686, Japan;2. Department of Clinical Laboratory Science, Faculty of Health Care, Tenri Health Care University, Tenri, Japan;3. Department of Rehabilitation Medicine, Osaka Medical College, Takatsuki, Japan;1. Kitajima ENT Clinic, 1-15-15 Tagara Nerima-ku, Tokyo 179-0073, Japan;2. Department of Otolaryngology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan;3. Department of Otolaryngology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511, Japan |
| |
| Abstract: | ObjectiveTo summarize the diagnosis and treatment outcomes of basal cell adenocarcinoma (BCAC) of the parotid gland, a rare low-grade malignancy, at a single institution, and to investigate the treatment approach for this rare malignancy.MethodsWe conducted a retrospective analysis of 9 patients with BCAC during 20 years from September 1999 to December 2019. Forty-five patients with basal cell adenoma (BCA), who were treated during the same time period, were used for comparison. The clinical characteristics of BCAC, diagnostic imaging, the usefulness of fine-needle aspiration cytology (FNAC) and frozen section biopsy (FSB), histological assessment of malignancy, and treatment outcomes were investigated.ResultsThere were no marked differences in sex, age, tumor diameter, or tumor location between BCAC and BCA cases. Among the 9 patients with BCAC, one patient was noted with pain/tenderness, and two patients were observed with adhesion to the surrounding tissues. Only one patient was diagnosed as malignant based on MRI/US. FNAC for BCAC was suspicious for malignancy in 6 of the 9 cases, which included one patient with the correct grade of malignancy, one patient with malignancy only, and 4 patients suspicious for malignancy. FSB was suspicious for malignancy in 8 of the 9 cases. Malignancy grade was determined based on infiltration to the surrounding tissues and expression of Ki-67, p53, and bcl-2. One patient with infiltration to the surrounding tissue was diagnosed as intermediate-grade malignancy, while the remaining 8 patients were diagnosed as low-grade malignancy. The BCAC cases included 7 patients with T2 and 2 patients with T1. Conservative resection was performed for all patients, and all cases are surviving cancer-free.ConclusionThe malignancy of BCAC can be suspected before surgery based on symptoms/signs, diagnostic imaging, and FNAC. FSB enables the diagnosis of not only malignancy but also the grade of malignancy, which may help determine the appropriate surgical resection. Although all 9 patients with BCAC are surviving free from cancer, a long-term follow-up is warranted. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
