Influence of basic fibroblast growth factor on the development of parkinsonian syndrome in mice |
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| Authors: | G. N. Kryzhanovskii V. G. Kucheryanu E. V. Nikushkin N. A. Krupina |
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| Affiliation: | (1) Laboratory of General Nervous System Pathology, Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | Intranasal administration of basic fibroblast growth factor prevented or reduced oligokinesia, muscular rigidity, and weight loss and also prevented mortality in mice with parkinsonism induced by repetitive intraperitoneal injections of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine. These beneficial effects are probably due to trophic actions of the factor, whereby the degeneration of nigrostriatal neurons is weakened and delayed and their survival is prolonged. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N o 9, pp. 260–262, September, 1995 |
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| Keywords: | parkinsonian syndrome basic fibroblast growth factor MPTP mice |
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