| 喉鳞状细胞癌组织中Survivin基因与p15和p16基因表达的关系 |
| |
| 摘 要： |
|
| 关 键 词： | 喉鳞状细胞癌 Survivin p15 p16 基因表达 抑癌基因 |
Expression of survivin gene and its relationship with expression of p15, p16 proteins in laryngeal squamous cell carcinomas] |
| |
| Authors: | Jin Zhu Ru-Jun Xu Zheng-Hu Wu Chun-Lan Yan Xiao-Lin Cao Yu Fang Lin Lin |
| |
| Institution: | Department of Otorhinolaryngology Head and Neck Surgery, Hangzhou First People's Hospital, Clinical Institute of Medical Science in Zhejiang Province, Hangzhou 310006, China. zhujinhyh@yahoo.com.cn |
| |
| Abstract: | OBJECTIVE:: To investigate the expression of Survivin (SVV) and its relationship with expression of p15, p16 in laryngeal squamous cell carcinoma (LSCC). METHODS: Using strep avidin-biotin complex (SABC) method, we examined the expression of SVV, p15 and p16 gene in 48 LSCC tissus samples, 24 normal laryngeal mucosa tissus samples and 24 normal laryngeal tissus adjacent to the tumors samples. RESULTS: SVV was expression in 27 of 48 (56.3%) samples of LSCC and expression in 6 of 24 (25.0%) samples of normal laryngeal tissus adjacent to the tumors. Normal laryngeal mocosa tissus samples did not expressed SVV. Overexpression of SVV was related to the tumor site, grade, clinical stage and tumor prognosis (P < 0.05). The expression of SVV in LSCC was positive correlated with p16 expression( C = 0.52 P < 0.001), but not with p15 expression. CONCLUSION: SVV may play a role in the pathway of carcinogenesis and tumor progress. It is feasible for early diagnosis and prognosis estimation. Overexpression of SVV gene and de-activation of antioncogene p16 may be play synergetic roles in the carcinogenesis of LSCC. |
| |
| Keywords: | |
|
|
