| HLA—Cw的免疫调节作用对肾移植受者长期存活的影响 |
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| 引用本文： | 吕凡彬,张岩,夏鹏,杨亦荣. HLA—Cw的免疫调节作用对肾移植受者长期存活的影响[J]. 中华移植杂志(电子版), 2012, 6(3): 209-213 |
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| 作者姓名： | 吕凡彬 张岩 夏鹏 杨亦荣 |
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| 作者单位： | 温州医学院附属第一医院移植科 |
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| 摘 要： | 排斥反应一直被视为肾移植后面临的主要难题,其发生是影响移植肾长期存活的重要因素。多项研究已证实HLA配型与移植后排斥反应的发生存在相关性。HLA-Cw作为经典的HLA—Ⅰ类分子以及杀伤细胞免疫球蛋白样受体的重要配体,其在移植免疫中的作用受到越来越多的关注。本文就HLA-Cw的免疫调节功能及其在肾移植免疫中的作用作一综述。
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| 关 键 词： | HLA-Cw 肾移植 排斥反应 |
Influence of HLA-Cw immunoregulation on the survival of renal transplant recipients |
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| LV Fan-bin, ZHANG Yan, XIA Peng, YANG Yi-rong. Influence of HLA-Cw immunoregulation on the survival of renal transplant recipients[J]. Chinese Journal of Transplantation (Electronic Edition), 2012, 6(3): 209-213 |
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| Authors: | LV Fan-bin ZHANG Yan XIA Peng YANG Yi-rong |
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| Affiliation: | . Transplantation Center, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China |
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| Abstract: | Rejection has been regarded as the main challenge after renal transplantation and HLA-A, -B and -DR have all turned out to be associated with rejection. HLA-Cw belongs to the classic HLA- I gene and is the important ligand of killer cell immunoglobulin-like receptor（ KIR）, thus it has been valued for its relation to transplantation immunity. In this article, we reviewed the immunomodulatory function of HLA-Cw and its role in renal tramsplantation immunity. |
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| Keywords: | HLA- Cw Renal transplantation Graft rejection |
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