类风湿关节炎患者血清白细胞介素-33水平与疾病进程的相关性

目的通过检测类风湿关节炎(RA)患者血清中白细胞介素(IL)-33水平,分析血清IL-33水平与RA的临床及实验室指标之间的相关性,验证IL-33参与RA的发病过程,探讨IL-33对于RA的临床意义。方法采用ELISA方法测定70例RA患者和30例健康对照者血清IL-33水平。结果 RA组血清IL-33水平为(231±335)pg/ml,高于健康对照组(6±23)pg/ml,P<0.01。高疾病活动度组血清IL-33水平为(351±391)pg/ml,高于中低疾病活动度组(145±266)pg/ml,P<0.05。RA患者血清IL-33水平与类风湿因子(RF)及抗环瓜氨酸肽(CCP)抗体呈正相关(P<0.01)。结论 IL-33参与了RA的发病过程,IL-33的升高可能提示RA预后不良。

Serum Level of Interleukin-33 in Patients with Rheumatoid Arthritis and Its Clinical Significance

Objective To test the serum level of interleukin （IL）-33 in patients with rheumatoid arthritis （RA） and analyze its correlation with both clinical and laboratory parameters. Methods Seventy patients with RA were selected, and 30 healthy controls were selected as controls. The serum IL-33 levels of the two groups were detected by enzyme-linked immunosorbent assay（ELISA）. Results The serum level of IL-33 in RA patients （231 ＋335）pg/ml] was higher than that of the healthy controls （6 ± 23） pg/ml, P 〈0. 01 ], the serum level of IL-33 in high disease activity group （351± 391 ）pg/ml] was higher than that of moderate and low disease activity group （ 145 ± 266 ） pg/ml, P 〈 0. 05 ]. The serum level of IL-33 was found to correlate with serum level of rheumatoid factor （RF） and anti-cyclic citrullinated peptide antibody （P 〈 0. 01 ）. Conclusion IL-33 is involved in the inflammatory process of RA, and IL-33 may predict worse prognosis for patients with RA.