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| 氯氰菊酯慢性染毒大鼠全血乙酰胆碱酯酶活性变化规律研究 | |
| 引用本文： | 姚茂忠,李林芳,陈湛娟.氯氰菊酯慢性染毒大鼠全血乙酰胆碱酯酶活性变化规律研究[J].海南医学院学报,2011,17(7):873-875. |
| 作者姓名： | 姚茂忠 李林芳 陈湛娟 |
| 作者单位： | 1. 海南医学院海南省药物安全性评价研究中心,海南海口,571101 2. 先声药业有限公司,海南海口,570216 3. 海南师范大学化学与化工学院,海南海口,571158 |
| 基金项目： | 海南省自然科学基金(808163)~~ |
| 摘 要： | 目的:探讨氯氰菊酯(CP)慢性染毒后大鼠全血乙酰胆碱酯酶(AChE)活性的变化规律.方法:120只80～100g雄性SD)大鼠随机分为4组,对照组(花生油)、低剂量组(40 mg/kg CP)、中剂量组(80mg/kg CP)和高剂量组(160 mg/kg CP),每组30只.灌胃给药28次,每日1次,共28 d,每日... |
| 关 键 词： | 氯氰菊酯 乙酰胆碱酯酶 活性 |
Variation of AChE activity of whole blood in rats after chronic exposure to cypermethrin |
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| YAO Mao-zhong,LI Lin-fang,CHEN Zhan-juan.Variation of AChE activity of whole blood in rats after chronic exposure to cypermethrin[J].Journal of Hainan Medical College,2011,17(7):873-875. | |
| Authors: | YAO Mao-zhong LI Lin-fang CHEN Zhan-juan |
| Institution: | YAO Mao-zhong1,LI Lin-fang2,CHEN Zhan-juan3(1.Research Center for Drug Safety Evaluation of Hainan Province,Hainan Medical University,Haikou 571101,2.Simcere Pharmaceutical Co.L.T.D.Haikou 570216,3.College of Chemistry and Chemical Engineering,Hainan normal University,Haikou 571158,China) |
| Abstract: | Objective: To investigate variation of acetylcholinesterase(AChE) activity of whole blood in rats after exposure to cypermethrin(CP).Methods: A total of 120 male SD rats(80-100g) were randomly divided into 4 groups,including control group(peanut oil),low dosage group(40 mg cp /kg body),middle dosage group(80 mg cp /kg body) and high dosage group(160 mg cp /kg body).Intragastric administration was carried out once a day for 28 days.General symptoms of rats were observed everyday.Blood was collected by tail a... |
| Keywords: | Cypermethrin Acetylcholinesterase Activity |
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