| 血管基膜衍生多功能肽抑制肺癌裸鼠移植瘤生长和血管生成 |
| |
| 引用本文： | 李辉,曹建国.血管基膜衍生多功能肽抑制肺癌裸鼠移植瘤生长和血管生成[J].湖南师范大学学报(医学版),2011,8(1):9-11,16. |
| |
| 作者姓名： | 李辉 曹建国 |
| |
| 作者单位： | 1. 郴州市第一人民医院,湖南郴州,423000
2. 湖南师范大学医学院,湖南长沙,410013 |
| |
| 基金项目： | 国家自然科学基金项目(30472040); 湖南省卫生厅重点项目(A2004-005) |
| |
| 摘 要： | 目的:研究重组血管基膜衍生多功能肽(rVBMDMP)对人肺癌裸鼠移植瘤生长和血管生成的抑制作用.方法:人肺癌A549裸鼠移植瘤模型治疗实验,评价rVBMDMP治疗人肺癌的有效性；CD34免疫组化染色检测rVBMDMP对移植瘤血管生成的影响.结果:rVBMDMP显著抑制人肺癌裸鼠移植瘤的生长,呈剂量依赖性趋势.与模型组相...
|
| 关 键 词： | 肺癌 血管基膜衍生多功能肽 血管生成 |
Recombinant vascular basement-membrane-derived multifunctional peptide inhibits the growth and angiogenesis of lung carcinoma in nude mouse xenograft model |
| |
| Li Hui,Cao Jianguo.Recombinant vascular basement-membrane-derived multifunctional peptide inhibits the growth and angiogenesis of lung carcinoma in nude mouse xenograft model[J].Journal of Hunan Normal University(Medical Science),2011,8(1):9-11,16. |
| |
| Authors: | Li Hui Cao Jianguo |
| |
| Institution: | Li Hui1,Cao Jianguo2(1.The First People's Hospital of Chenzhou City,Chenzhou 423000,China,2.Medical College,Hunan Normal University,Changsha 410013,China) |
| |
| Abstract: | Objective To investigate the inhibitory effects of recombinant vascular basement-membrane-derived multifunctional peptide(rVBMDMP) on the growth and angiogenesis of human lung carcinoma in nude mouse xenograft model.Methods Human lung cancer in nude xenograft mouse model was employed to evaluate the therapeutic effect of rVBMDMP in vivo.The anti-angiogenic effect of rVBMDMP was detected using immunohistochemical staining for CD34.Results rVBMDMP significantly inhibited tumor growth of human lung carcinoma i... |
| |
| Keywords: | lung cancer recombinant vascular basement membrane derived multifunctional peptide angiogenesis therapeutic action |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
