Synthesis and antimycobacterial activity of some heteroarylcarboxamidrazone derivatives. |
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| Authors: | D C Billington M D Coleman J Ibiabuo P A Lambert D L Rathbone K J Tims |
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| Affiliation: | Pharmaceutical Sciences Institute, Aston University, Aston Triangle, Birmingham, UK. |
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| Abstract: | A series of pyridine-2-, pyrazine-2- and quinoline-2-carboxamidrazone derivatives was prepared in an automated fashion and tested against Mycobacterium fortuitum in a rapid screen. Seven pyridine-2-carboxamidrazone derivatives were investigated further and four were found to have inhibitory activity with compound 4af being the most active. The structure activity implications are discussed. |
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