nm23基因、CD44v6的表达及微血管密度与直肠癌预后的关系

目的：探讨nm23基因、CD44v6的表达及微血管密度（microvessel density, MVD）在直肠癌预后中的意义。方法：采用免疫组化法检测70例直肠癌组织中nm23基因和CD44v6的表达以及MVD，并结合随访资料进行生存分析。结果：nm23基因的表达与组织学类型无关，与浸润深度、UICC分期和淋巴结转移相关；CD44v6的表达和MVD与以上各项因素均相关。单因素生存分析显示，UICC分期、淋巴结转移、nm23基因的表达和CD44v6的表达以及MVD都与直肠癌的预后有关。但经多因素分析，只有UICC分期和nm23基因的表达具有独立的预后意义。结论：UICC分期和nm23基因的表达可作为判断直肠癌预后的独立指标。

nm23 and CD44v6 protein expression and microvessel density relate to the prognosis of rectal carcinoma

Objective: To investigate the expression of nm23,CD44v6 and the microvessel density(MVD) in rectal carcinoma and analyze their relationship with prognosis.Methods: The expressions of nm23 and CD44v6 and the MVD were examined using immunohistochemical technique in 70 cases of rectal carcinoma,and the prognosis was analyzed.Results: The expression of nm23 had correlation with the depth of infiltration,the UICC staging and the lymph node metastasis.Both the expression of CD44v6 and the MVD had correlation with the histological type,the depth of infiltration,the UICC staging and the lymph node metastasis.Kaplan-Meier survival analysis revealed that the survival rate was correlated with the UICC staging,the lymph node metastasis and the expressions of nm23 and CD44v6 and the MVD.However,Cox proportional hazards analysis showed that only UICC staging and the expression of nm23 retained independently in prospecting prognosis.Conclusion: The UICC staging and the expression of nm23 are considered as the independent parameters in predicting the prognosis of rectal carcinoma.