| 寻常型银屑病单纯病例研究 |
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| 引用本文： | 魏生才, 李明, 高敏, 张学军, 王再兴, 杨森. 寻常型银屑病单纯病例研究[J]. 中国公共卫生, 2002, 18(12): 1451-1453. DOI: 10.11847/zgggws2002-18-12-24 |
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| 作者姓名： | 魏生才 李明 高敏 张学军 王再兴 杨森 |
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| 作者单位： | 1.安徽医科大学皮肤病研究所、第一附属医院皮肤科 合肥230032 |
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| 基金项目： | 国家863资助研究项目(Z-19-01-04-04);安徽省自然科学基金资助研究项目(99044237) |
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| 摘 要： | 目的 研究寻常型银屑病环境因素与HLA-DQA1*0104、DQA1*0201和DQA1*0501等位基因的交互作用.方法 采用单纯病例研究方法,调查176例寻常型银屑病患者环境因素,用PCR-SSP方法检测HLA-DQA1*0104、DQA1*0201和DQA10501等位基因,对寻常型银屑病环境因素与HLA-DQA1*0104、DQA1*0201和DQA1*0501等位基因交互作用进行研究.结果 (1)HLA-DQA1*0104等位基因与精神紧张呈现交互作用(P=0.0383,OR=0.41).(2)HLA-DQA1*0201等位基因与饮酒(P=0.0451,OR=0.52)、手术(P=0.0332,OR=3.93)存在交互作用.(3)HLA-DQA10501等位基因与接种疫苗(P=0.0145,OR=12.0)存在交互作用.结论 HLA-DQA1*0104、DQA1*0201和DQA1*0501等位基因能加强或减弱环境因素发生银屑病的危险性.
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| 关 键 词： | 银屑病 环境因素 HLA-DQA1等位基因 交互作用 |
| 文章编号： | 1001-0580(2002)12-1451-03 |
| 收稿时间： | 2001-12-05 |
| 修稿时间： | 2001-12-05 |
Case - merely Study on Psoriasis Vulgaris |
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| WEI Sheng-cai, LI Ming, GAO Min, . Case-merely Study on Psoriasis Vulgaris[J]. Chinese Journal of Public Health, 2002, 18(12): 1451-1453. DOI: 10.11847/zgggws2002-18-12-24 |
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| Authors: | WEI Sheng-cai LI Ming GAO Min |
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| Affiliation: | 1.Institute of Dermatology, Department of Dermatology, the First Affiliated Hospital of Anhui Medical University, Hefei 230032, China |
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| Abstract: | Objective To study the HLA-DQA1 *0104,DQA1 *0201,DQA1 *0501 alleles and environmental factors interaction in psoriasis vulgaris.Methods Using case-merely study,176 psoriatics were investigated.The HLA-DQA1 *0104,DQA1*0201 and DQA1*0501 alleles were examined by PCR-SSP.Results (1)The HLA-DQA1*0104 allele and stress were interaction in psoriasis(P=01038 3,OR=0141).(2)The HLA-DQA1*0201 allele,drinking(P=0.045 1,OR=0.52)or operation(P=0.033 2,OR=3.93)were interaction in psoriasis.(3)The HLA-DQA1*0501 allele and vaccination(P=0.014 5,OR=12.0)were interaction in psoriasis.Conclusion The HLA-DQA1*0104,DQA1*0201 and DQA1*0501 alleles improved or reduced risk possibility of environmental factors in psoriasis. |
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| Keywords: | psoriasis vulgaris environmental factors HLA-DQA1 alleles interaction |
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