刺五加注射液改善胃肠道肿瘤病人术后疲劳综合征的临床研究

目的探讨胃肠道肿瘤病人在充足营养底物支持下,应用刺五加注射液能否减轻术后疲劳综合征(POF)。方法选择45例接受中等以上腹部手术的胃肠道肿瘤病人,随机分组进行双盲试验,两组病人术后给予相同标准的营养底物,刺五加注射液治疗组于术后第1天起给刺五加注射液静脉滴注,一次100ml,一日2次,连续用10天;对照组给予安慰剂。监测病人术后疲劳评分、氮平衡、前白蛋白、转铁蛋白及体重。结果于术后7.14天刺五加注射液治疗组疲劳评分(Christensen's评分)明显低于对照组(P<0.001);排氮量明显低于对照组(P<0.001);前白蛋白及转铁蛋白下降明显低于对照组(P<0.001);两组体重均有下降,治疗组下降明显低于对照组(P<0.05)。结论应用刺五加注射液有利于胃肠道肿瘤病人术后POF。

Clinical investigation of acanthopanax root injection for improving the postoperative fatigue syndrome of the patients with gastro-intestinal tumors

Objectives To investigate weather the acanthopanax root injection can shorten the duration of the postoperative fatigue syndrome of the patients with gastrointestinal tumour under the support of sufficient basic nutrition-substance. Methods 45 cases of gastro-intestinal tumors were chosen,they had received the medium-upper sized abdominal operations.They were randomly divided into two groups to receive the double blind test. The same basic standard nutritional foods were given to the patients of the two groups after operations. The acanthopanax root injection was given to the cases of acanthopanx root injection group by dripping from the first day. 100ml per time two times daily were given continually for 10 days; the placebo was given to the control-group. The estima- tions of postoperative fatigue,nitrogen balance,prealbumin,transferrin and body-weight were given to the patients. Results The fatigue estimations of the therapeutic group (Christensen's estimation)of acanthopanax root injection,7.14days after operation,were markedly lower than the control group(P < 0.001);The elimination of nitrogen was markedly lower than the control group (P < 0.001);the lowering of the prealbumin and transferring were markedly lower than the control group(P < 0.001) The body weight of the two groups all were dropped but the body weight of the test group was markedly lower than the control group (P < 0.05).Conclusion The use of the acanthopanax root injection is beneficial to shorten the duration of the postoperative fatigue syndrome of patients with gastro- intestinal tumours.