Increased expression of MUC1 predicts poor survival in salivary gland mucoepidermoid carcinoma |
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| Institution: | 1. Department of Oral & Maxillofacial-Head & Neck Oncology, Ninth People''s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomotology, 639 Zhi Zao Ju Road, Shanghai 200011, PR China;2. Department of Oral Pathology, Ninth People''s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomotology, PR China;1. Department of Head and Neck Surgery, Fuzhou General Hospital, Nanjing Command Zone of PLA, Fuzhou, China;2. Department of Bioinformatics, Fuzhou General Hospital, Nanjing Command Zone of PLA, Fuzhou, China;3. Department of Oncology, Fujian Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350112, China;1. Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil;2. Department of Anesthesiology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil;1. Associate Professor, Department of Orthodontics, University of Iowa College of Dentistry, Iowa City, IA, USA;2. Assistant Professor, Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA, USA;1. Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Nazloo Road, Urmia 57153 1177, Iran;2. Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran;3. Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4, Canada;1. Department of Plastic and Reconstructive surgery, Soonchunhyang University Hospital, 59 Daesagwan-ro, Yongsan-gu, Seoul, Republic of Korea;2. Department of Plastic and Reconstructive surgery, Hanyang University Guri Hospital, 153, Gyeongchun-ro, Guri-si, Gyeonggi-do, Republic of Korea |
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| Abstract: | BackgroundMucoepidermoid carcinoma (MEC) is a malignant neoplasm that originates most commonly in the major and minor salivary glands. The aim of this study is to determine the relationship between mucin-1 (MUC1) expression and patient outcome based on a large number of cases.Patients and methodsSurgical specimens from 357 patients with primary salivary gland MEC and 10 patients with normal salivary gland tissue were examined by immunohistochemistry. The relationship between MUC1 expression and the clinicopathological data and patient survival was analyzed.ResultsResults showed that MUC1 expression level was higher in MEC tissues than in paired normal tissues (P = 0.001), and the expression level of MUC1 was significantly associated with gender (P = 0.02), location (P = 0.001), grade (P = 0.001), stage (P = 0.0018) and lymph node metastasis (P = 0.001). In addition, increased expression of MUC1 was confirmed as a strong predictor of poor survival in salivary gland MEC (HR 2.175 95% CI 1.263, 3.745]; P = 0.0051).ConclusionThe findings indicate that an increased expression of MUC1 may be of great value in assessing the development and prognosis of salivary gland MEC, and could be used as a new molecule target to improve outcomes for these patients in the future. |
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| Keywords: | Mucoepidermoid carcinoma (MEC) Salivary gland MUC1 Lymph node metastasis Prognosis |
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