乳腺癌保乳术后大分割与常规分割放疗的皮肤副作用及美容效果比较:基于倾向性评分匹配法

  目的  使用倾向性评分匹配法对组间协变量进行均衡处理后，比较乳腺癌保乳术后大分割放疗与常规分割放疗的美容效果和皮肤副反应。  方法  回顾性分析2015年1月~2018年7月在深圳市人民医院进行放射治疗的319例保乳术后的乳腺癌患者，其中大分割放疗组215例，常规分割放疗组104例，通过对两组患者进行倾向性评分匹配，获得协变量均衡的两组新样本，并对这两组样本进行分析。  结果  经过倾向性评分匹配后的常规分割放疗组99例，大分割放疗组100例。两组患者I级早期皮肤副反应分别为67.6%和78%，分别有14.1%和10%的患者出现湿性脱皮，差异无统计学意义（P=0.111）。在第6月、1年、2年的I级皮肤副反应发生率分别为86.9%，90.0%；96.0%，92.0%；99.0%，96.0%，（P=0.471），两组均未出现III级及以上的晚期皮肤毒副作用。2年后常规分割组与大分割组美容评价良好率分别为78.8%、84.0%（P=0.361）。  结论  对于早期乳腺癌保乳术后的辅助放疗，大分割放疗与常规放疗的皮肤毒副反应和美容效果均无显著差异。 

Comparison of skin side effection and cosmetic effection of postoperative hypofraction and conventional fractional radiotherapy for early breast cancer patiens with breast-conserving surgery: based on propensity score matching method

  Objective  To compare the side effection of skin and cosmetic scores between postoperative hypofraction radiotherapy and convention fraction radiotherapy for early breast cancer patiens with breast-conserving surgery, through balancing the covariates of the two groups with propensity score matching method.  Methods  The patients (n=319) who underwent breast-conserving surgery at Shenzhen People's Hospital from Jan. 2015 to Jul. 2018 were retrospectively analyzed. There were 104 patients in the hypofraction radiotherapy group and the other 215 patients in the convention fraction radiotherapy group, which matched by propensity scores to obtain two new groups with balanced covariates.We analyzed the samples of the two groups.  Results  There were 99 patients in the convention fraction radiotherapy group and 100 patients in the hypofraction radiotherapy group after propensity score matched. There were 86.9% and 90% patients presented early skin side effection, respectively. The 14.1% and 10% of patients in the two groups occured wet peeling, which had no significant difference (P=0.111). The incidence of grade I skin side effection in the two groups at 6 months, 1 year, and 2 years were 86.9%, 90.0%; 96.0%, 92.0%; 99.0%, 96.0%(P=0.471). There were no late grade III or worse skin side effection in the two groups. The good rates of cosmetic scores between the convention fraction radiotherapy group and hypofraction radiotherapy group were 78.8% and 84.0% (P=0.361) after 2 years.  Conclusion  There is no significant difference in side effection of skin or cosmetic scores between postoperative hypofraction radiotherapy and convention radiotherapy for early breast cancer patiens with breast-conserving surgery.