血管内皮生长因子、细胞周期相关核抗原Ki-67抗体和p53表达水平与脑膜瘤术后瘤周水肿的相关性研究

目的 探讨血管内皮生长因子(Vascular endothelial growth factor,VEGF)、细胞周期相关核抗原Ki-67抗体和p53的表达水平对脑膜瘤术后瘤周水肿(Pedtumoral brain edema,PTBE)的影响.方法 选取2007年1月-2016年7月于本院就诊的脑膜瘤手术患者159例...

The relationship between VEGF,Ki-67 antibody,p53, and PTBE and postoperative peritumoral edema of meningioma

ObjectiveTo investigate the effects of vascular endothelial growth factor(VEGF), cell cycle-associated nuclear antigen Ki-67 antibody, and p53 expression on peritumoral edema(PTBE)after meningioma surgery.Methods A total of 159 cases with meningioma from January 2007 to July 2016 were enrolled in this hospital. The expression of VEGF, Ki-67, and p53 were detected by immunohistochemistry. The degree of PTBE was detected by MRI. The baseline data and the levels of VEGF, Ki-67 antibody and p53 in no Edema group without obvious edema were compared with those in the edema group with significant edema.Results PTBE was not related to sex, age, BMI, hypertension, diabetes, and preoperative epilepsy, but was closely related to preoperative peritumoral edema, tumor location, tumor diameter, tumor shape, tumor boundary, tumor classification, Simpson level, WHO grade, VEGF, Ki-67 antibody and p53. Among them, proximal sinus meningioma, tumor diameter ≥ 5 cm, mushroom meningioma, unclear tumor boundary, endothelial meningioma, Simpson grade, WHO grade and high expression of VEGF, p53 and Ki-67 antibody were all risk factors affecting the prognosis of PTBE. Preoperative peritumoral edema was a protective factor(P<0.05). The expressions of VEGF, p53 and Ki-67 antibody were significantly up-regulated with the severity of PTBE(P<0.05). The 3-year survival rate of VEGF-, p53- and Ki-67 antibody -positive patients was significantly lower than that of VEGF-, p53- and Ki-67 antibody negative patients(p<0.05).Conclusion The occurrence of peritumoral edema after meningioma is not only related to general clinical features and tumor features, but also closely related to the expression of VEGF, Ki-67 antibody and p53. VEGF, Ki-67 antibody and p53 are highly expressed in peritumoral edema after meningioma operation and positively correlated with each other, which are the key risk factors for poor prognosis.