细胞免疫应答变化与支气管哮喘疾病进展的相关性分析

目的 探讨细胞免疫应答变化与支气管哮喘疾病进展的相关性.方法 选取95例支气管哮喘患者为观察组,选取同期体检的健康人95例为对照组,记录研究对象辅助性T细胞1(T helper cells 1,Thl)、Th2、Th17和调节性 T 细胞(regulatory cell,Treg)比例,记录白细胞介素-2(interl...

Correlation between changes of cellular immune response and progression of severe bronchial

Objective To investigate the correlation between changes in cellular immune responses and progression of severe bronchial asthma. Methods Ninty-five patients with severe bronchial asthma who were treated in Anyang District Hospital and Henan People′s Hospital from May 2017 to May 2018 were selected as the study group; and 95 healthy people who were examined in Anyang District Hospital and Henan People′s Hospital during the same period were selected as the control group. T helper cells 1 (TH1), Th2, Th17 and regulatory cell (Treg) ratio were assessed. Interleukin-2 (IL-2), IL-4, interferon-γ(IFN-γ), IL-10, IL-17, transforming growth factor-β(TGF-β), IL-22 mRNA and protein expression levels were also recorded. The blood CD3+, CD4+, CD8+ and CD4+/CD8+ levels were compared. Results The proportion of Treg and Th1 cells in the study group was significantly lower than that in the control group (P<0.05); and the proportion of Th2 and Th17 cells was significantly higher than that of the control group (P<0.05). The Th1/Th2 in the study group was significantly lower than that in the control group, and the Th17/Treg was significantly higher than the control group (P<0.05). The levels of CD4+/CD8+, CD8+, CD3+ and CD4+ in the study group were significantly lower than those in the control group (P<0.05). The expression levels of TGF-β, IL-2 and IFN-γ protein in the study group were significantly lower than those of the control group, and the expression levels of IL-22, IL-17, IL-4 and IL-10 were significantly higher than those of the control group (P<0.05).