黄芪补气汤联合还原型谷胱甘肽对肝癌介入治疗后患者肝功能、氧化应激及炎症的影响

目的:观察黄芪补气汤联合还原型谷胱甘肽对原发性肝癌(PLC)介入治疗后肝功能、氧化应激及炎症的影响。方法:选择PLC患者84例,随机分为对照组和观察组各42例。患者均给予肝动脉介入治疗,对照组术后给予还原型谷胱甘肽治疗,观察组在此基础上给予加味黄芪补气汤治疗。比较治疗前及4周后两组血清总胆红素(TBIL)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)、超氧化物歧化酶(SOD)、丙二醛(MDA)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)变化及总有效率,观察两组不良反应发生情况。结果:两组治疗前TBIL、ALT、AST、ALP、SOD、MDA、TNF-α、IL-6比较,差异无统计学意义(P>0.05); 治疗4周后,两组TBIL、ALT、AST、ALP、SOD均升高,MDA、TNF-α、IL-6均降低(P<0.05); 观察组治疗4周后SOD高于对照组,TBIL、ALT、AST、ALP、SOD、MDA、TNF-α、IL-6均低于对照组(P<0.05); 观察组总有效率高于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:黄芪补气汤联合还原型谷胱甘肽可明显改善经介入治疗后肝癌患者的肝功能、降低氧化应激及炎症反应水平。

Effect of Huangqi Buqi decoction combined with reduced glutathione on liver function,oxidative stress and inflammation after interventional therapy for hepatocellular carcinoma

Objective:To observe the effect of Huangqi Buqi decoction combined with reduced glutathione on liver function,oxidative stress and inflammation in patients with primary liver cancer(PLC)after interventional therapy.Methods:84 cases of PLC patients were selected.They were randomly divided into control group(n=42)and observation group(n=42).All patients were given hepatic artery interventional therapy,the control group was given reduced glutathione treatment after operation,and the observation group was given modified Huangqi Buqi decoction on the basis of the control group.The changes of serum TBIL,ALT,AST,ALP,SOD,MDA,TNF-α,IL-6 and the total effective rate were compared between the two groups before treatment and after 4 weeks.Results:There was no significant difference in TBIL,ALT,AST,ALP,SOD,MDA,TNF-α,IL-6 between the two groups before treatment(P>0.05).After 4 weeks of treatment,TBIL,ALT,AST,ALP,SOD in the two groups were increased,MDA,TNF-α,IL-6 were decreased(P<0.05); SOD in the observation group was higher than that in the control group,TBIL,ALT,AST,ALP,SOD,MDA,TNF-α,IL-6 were lower than those in the control group(P<0.05).The effective ratewas significantly higher than in the control group(P<0.05).There was no significant adverse reaction in both groups(P>0.05).Conclusion:Huangqi Buqi decoction combined with reduced glutathione can significantly improve liver function,reduce oxidative stress and inflammatory reaction in patients with liver cancer after interventional therapy.