基于SEER数据库的甲状腺髓样癌预后分析

目的:探索影响甲状腺髓样癌的预后因素.方法:通过SEER*Stat软件收集SEER数据库中于2004-2015年行全甲状腺切除+淋巴结清扫,病理诊断明确提示为甲状腺髓样癌的867例患者,运用单因素与多因素Cox回归分析影响患者生存的独立因素,并分析独立危险因素的KM生存曲线.结果:纳入的867例患者平均随访时间60(2...

Prognostic analysis of medullary thyroid carcinoma based on SEER data

Objective: To explore the prognostic factors affecting medullary thyroid carcinoma（MTC）. Methods: SEER*Stat software was used to collect 867 patients with MTC from 2004 to 2015 who had total thyroidectomy and lymphadenectomy and whose pathological diagnosis was definite.Univariate and multivariate Cox regression was used to analyze the independent factors affecting the survival of patients, and to analyze the KM survival curve of independent risk factors. Results: The included 867 patients had an average follow-up time of 60（29-94） months，a 3-year tumor-specific survival rate of 96.1%，and a 5-year tumor-specific survival rate of 95.1%. Univariate Cox results suggested gender（HR=0.57，95% CI:0.337-0.973，P=0.039），age（HR=3.12，95% CI:2.06-4.71，P<0.001），tumor size（HR=3.02，95%CI:2.10-4.34，P<0.001）， M stage（HR=12.9，95%CI:7.38-22.4，P<0.001) and lymph node ratio（LNR）（HR=3.00, 95%CI:2.17-4.14，P<0.001） are related to the survival time of patients. Multivariate Cox regression analysis shows that age（HR=3.43，95%CI:2.23-5.27，P<0.001），tumor size（HR=1.96，95%CI:1.36-2.83，P<0.001），M stage（HR=7.03，95%CI:3.82-12.9，P<0.001），number of positive lymph nodes（HR=2.07，95%CI:1.62-2.65，P<0.001） and lymph node ratio（HR=2.24，95%CI:1.59-3.15，P<0.001) were independent risk factors for patients with MTC undergoing total thyroidectomy and lymph node dissection. Conclusion: Age, tumor size, M stage and LNR are independent risk factors that affect the survival of patients with MTC undergoing total thyroidectomy and lymph node dissection.