Metastasizing “benign” pleomorphic salivary adenoma: A dramatic case-report and literature review |
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| Institution: | 1. Maxillofacial Surgery Unit, Alma Mater Studiorum University of Bologna, Bologna, Italy;2. ENT Unit, Alma Mater Studiorum University of Bologna, Bologna, Italy;3. Department of Hematology and Oncology, Section of Pathological Anatomy, Bellaria Hospital, University of Bologna, Bologna, Italy;1. Department of Head and Neck Surgery, Fuzhou General Hospital, Nanjing Command Zone of PLA, Fuzhou, China;2. Department of Bioinformatics, Fuzhou General Hospital, Nanjing Command Zone of PLA, Fuzhou, China;3. Department of Oncology, Fujian Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350112, China;1. Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Nazloo Road, Urmia 57153 1177, Iran;2. Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran;3. Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4, Canada;1. Department of Plastic and Reconstructive Surgery, Chiba University, Graduate School of Medicine, Japan;2. Department of Neurosurgery, Showa University, Japan;1. Department of Plastic and Reconstructive surgery, Soonchunhyang University Hospital, 59 Daesagwan-ro, Yongsan-gu, Seoul, Republic of Korea;2. Department of Plastic and Reconstructive surgery, Hanyang University Guri Hospital, 153, Gyeongchun-ro, Guri-si, Gyeonggi-do, Republic of Korea;1. Department of Urology, University of California-Irvine, Irvine, California;2. Department of Urology and Nephrology Center, Mansoura University, Mansoura, Egypt;3. Department of Helios Klinikum Wuppertal, University Witten-Herdecke, Germany;4. Department of Urology, Baylor College of Medicine, Houston, Texas;5. Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas;6. Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas;1. Departments of Oral and Maxillofacial Surgery, Portsmouth Hospitals NHS Trust, Portsmouth, PO6 3LY, UK;2. Histopathology, Portsmouth Hospitals NHS Trust, Portsmouth, PO6 3LY, UK;3. Clinical Oncology, Portsmouth Hospitals NHS Trust, Portsmouth, PO6 3LY, UK |
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| Abstract: | Pleomorphic salivary adenomas are the most common benign neoplasms affecting the salivary glands. Very occasionally however, metastatic lesions are identified in patients with a history of PSA, which, on detailed pathological evaluation, are found to exhibit all the histological hallmarks of the preceding benign lesions.Diagnosis of benign metastasizing pleomorphic adenoma of the salivary gland is extremely rare and still under debate.We present the first case-report in literature of multiple metachronous nasal cavity, scalp and encephalic metastases of a pleomorphic adenoma of the parotid gland in a young girl. |
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| Keywords: | Metastasizing pleomorphic salivary adenoma Parotid gland tumours Multiple pleomorphic adenomas |
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