临时性泪道塞联合地夸磷索钠滴眼液治疗中重度干眼的效果

目的 探讨临时性泪道塞联合地夸磷索钠滴眼液治疗中重度干眼的临床疗效。方法选择收治的中重度干眼患者80例，依照随机数字表法分为对照组和观察组，每组40例。对照组给予地夸磷索钠滴眼液治疗，观察组给予临时性泪道塞联合地夸磷索钠滴眼液治疗，两组均治疗4周。治疗后进行临床疗效评价。比较两组治疗前后主观症状评分、角膜荧光染色评分、泪膜破裂时间（BUT）及泪液分泌实验（STI）。比较两组治疗过程中的不良反应。结果观察组的临床总有效率明显高于对照组（P<0.05）。两组治疗后主观症状评分、角膜荧光染色评分均明显小于治疗前（P<0.05），同时观察组治疗后主观症状评分、角膜荧光染色评分均明显小于对照组（P<0.05）。两组治疗后BUT、STI均明显大于治疗前（P<0.05），同时观察组治疗后BUT、STI明显大于对照组（P<0.05）。治疗期间，观察组的不良反应发生率为12.50%（5/40），对照组为10.00%（4/40），两组比较差异无统计学意义（2=0.000，P=1.000）。结论临时性泪道塞联合地夸磷索钠滴眼液治疗中重度干眼临床疗效显著，能够明显缓解临床症状，改善视功能，且安全性较好。

Clinical research of temporary lacrimal passage stopper combined with diquafosol sodium eye drops in the treatment of moderate and severe xerophthalmia

Objective To investigate the clinical efficacy of temporary lacrimal passage stopper combined with diquafosol sodium eye drops on the treatment of moderate and severe xerophthalmia. Methods Eighty patients with moderate and severe xerophthalmia were selected, and randomly divided into the control group (40 cases) and the observation group (40 cases). The control group was treated with diquafosol sodium eye drops for 4 weeks, and the observation group was treated with temporary lacrimal passage stopper combined with diquafosol sodium eye drops for 4 weeks. After treatment, the clinical efficacy was evaluated. The subjective symptom scores, conjunctiva fluorescence staining scores, BUT, and STI of the two groups were compared before and after treatment. The adverse reactions were compared between the two groups. Results The total clinical effective rate of the observation group was statistically significantly higher than that of the control group (P<0.05). After treatment, the subjective symptom scores, conjunctiva fluorescence staining scores in the two groups were significantly lower than those before treatment (P<0.05), the BUT, STI in the two groups were significantly higher than those before treatment (P<0.05), and those of the observation group were significantly better than those in the control group (P<0.05). During the treatment, the incidence of adverse reactions was 12.50% (5/40) in the observation group and 10.00% (4/40) in the control group. There was no significant difference between the two groups (2=0.000, P=1.000). Conclusion The therapeutic effect of temporary lacrimal passage stopper combined with diquafosol sodium eye drops on the treatment of moderate and severe xerophthalmia is significant, which can significantly reduce the clinical symptoms, improve the eye function, and has good safety.