From bench to application: Current practices in tissue engineering and its realisation at maxillofacial units in Germany,Austria and Switzerland |
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| Affiliation: | 1. Department of Oral and Maxillofacial Surgery (Head: Prof. Dr. med. Dr. med. dent. Max Heiland), University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany;2. Department of Oral and Maxillofacial Surgery (Head: Prof. Dr. med. Dr. med. dent. Jürgen Hoffmann), University Hospital Heidelberg, Im Neuenheimer Feld 672, 69120 Heidelberg, Germany;3. Doctor''s Office, Kärntner Straße 62, 9900 Lienz, Austria;4. Department of Oral and Maxillofacial Surgery (Head: Prof. Dr. med. Dr. med. dent. Klaus Dietrich Wolff), Klinikum rechts der Isar der Technischen Universität München, Ismaninger Straße 22, 81675 München, Germany;1. Department of Oral and Maxillofacial Surgery, Çorlu Military Hospital, Tekirdağ 59186, Turkey;2. Department of Oral and Maxillofacial Surgery, Gülhane Military Medical Academy, Ankara, Turkey;3. Department of Prosthodontics, Çorlu Military Hospital, Tekirdağ, Turkey;1. The State Key Laboratory of Oral Diseases and West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;2. Department of Cosmetic Surgery, The Third Hospital of Chengdu, Chengdu 610031, China;1. Center of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia;2. Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia;1. Department of Mathematics, Howard University, Washington, DC 20059, USA;2. Department of Pure Mathematics and Mathematical Statistics, Centre for Mathematical Sciences, Wilberforce Road, Cambridge, CB3 0WB, UK;3. Department of Pure Mathematics, University of Leeds, Leeds LS2 9J2, UK |
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| Abstract: | Over the last 20 years, the highly interdisciplinary field of tissue engineering (TE) has become an established subspecialty in research facilities all over the world. Numerous methods and protocols are available for various research intentions and aims, but there are no data indicating which of these methods and resources are generally used. This study is an overview of the resources and methods that are commonly applied in TE research in general, and in the field of oral and maxillofacial surgery (OMFS) in Germany, Austria and Switzerland.The DÖSAK collaborative group for TE developed a detailed questionnaire and collected information from participating university hospitals in these three countries. We evaluated the availability of research facilities, in vitro realisation and in vivo designs for animal studies in these departments.11 units who replied, out of 35 we contacted, conducted research on bone regeneration in interdisciplinary research facilities. 10 departments used xenogeneic and alloplastic scaffolds for in vitro and in vivo applications. In this case, the most commonly utilised trademarks were Bio-Oss® and CERASORB®.9 units used osteoblasts (73%) and 10 proliferation assays in vitro, whereas rats served as the standard animal model for histology/immunohistochemistry in 6. All research units were interested in establishing a platform for research exchange and communication.This study shows that tissue engineering is well established and highly accepted in most participating university hospitals and research facilities. The presented data, together with data published in a foregoing paper will help arrange more readily available standardised procedures for further investigations. |
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| Keywords: | Tissue engineering Scaffolds Bone substitute materials DÖSAK |
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