急性脑梗死患者血清CTRP3,CTRP9水平与颈总动脉内膜中层厚度的相关性分析

目的 探讨急性脑梗死(Acute cerebral infarction,ACI)患者血清中补体C1q/肿瘤坏死因子相关蛋白3/9(Complement-C1q/tumor necrosis factor-related protein 3/9,CTRP3/9)的水平变化及其与颈总动脉内膜中层厚度(Carotid intima-media thickness,CIMT)的相关性。方法 选取2015年12月-2019年1月本院收治的102例ACI患者进行研究(ACI组),并选取同时间段内98例体检健康者进行对照分析研究(对照组); 分析比较2组受试者一般资料; 采用酶联免疫吸附法(Enzyme linked immunosorbent assay,ELISA)检测2组受试者血清CTRP3,CTRP9水平; 利用彩色多普勒超声仪检测2组受试者CIMT; Pearson法分析ACI患者血清CTRP3,CTRP9水平与CIMT以及CTRP3与CTRP9水平的关系; 采用Logistic回归分析法ACI患者CIMT的影响因素。结果 ACI组血清低密度脂蛋白-胆固醇(Low density lipoprotein cholesterol,LDL-C)、总胆固醇(Total cholesterol,TC)、甘油三酯(Triglyceride,TG)水平均高于对照组(P<0.05),血清CTRP3,CTRP9、高密度脂蛋白-胆固醇(HDL-C)水平明显均明显低于对照组(P<0.05),CIMT较对照组增加(P<0.05); ACI患者血清CTRP3与CTRP9水平呈正相关(r=0.490,P<0.05),血清CTRP3,CTRP9水平与CIMT均呈负相关(r=-0.461、-0.482,P<0.05); TG,TC,LDL-C水平为ACI患者CIMT增加的危险因素(P<0.05),HDL-C,CTRP3,CTRP9水平为ACI患者CIMT增加的保护因素(P<0.05)。结论 ACI患者血清CTRP3,CTRP9水平均明显降低,两者可能与CIMT相互影响,共同影响ACI发生发展。

The correlation between serum CTRP3 and CTRP9 levels and carotid intima-media thickness in patients with acute cerebral infarction

ObjectiveTo investigate the complement C1q/tumor necrosis factor-related protein-3(CTRP3)and complement C1q/tumor necrosis factor-related protein-9(CTRP9)level changes in serum of patients with acute cerebral infarction(ACI)and their correlation with carotid intima-media thickness(CIMT).Methods A total of 102 patients with ACI admitted to our hospital from February 2016 to January 2019 were selected for the study(ACI group), and 98 healthy persons in the same period were selected for the control analysis study(control group). The general data of the two groups were analyzed and compared, the serum CTRP3 and CTRP9 levels were detected by enzyme-linked immunosorbent assay(ELISA), the CIMT was detected by color Doppler ultrasound. Pearson method was used to analyze the relationships between serum CTRP3, CTRP9 levels and CIMT, and the relationship between CTRP3 and CTRP9 levels, and Logistic regression analysis was used to analyze the influencing factors of CIMT in ACI patients.Results The low density lipoprotein cholesterol(LDL-C), total cholesterol(TC)and triglyceride(TG)levels in ACI group were significantly higher than those in control group(P<0.05), the CTRP3, CTRP9 and high density lipoprotein cholesterol(HDL-C)levels in serum were significantly lower than those in the control group(P<0.05), and CIMT was thicker than that in control group(P<0.05), the serum CTRP3 level of ACI patients was positively correlated with CTRP9 level(r=0.490,P<0.05), and the serum CTRP3 and CTRP9 levels were negatively correlated with CIMT(r=-0.461、-0.482,P<0.05). TG, TC and LDL-C levels were risk factors of CIMT thickening in ACI patients(P<0.05), while HDL-C, CTRP3 and CTRP9 levels were protective factors of CIMT thickening in ACI patients(P<0.05).Conclusion The serum CTRP3 and CTRP9 levels in patients with ACI were significantly reduced. They might interact with CIMT, and jointly affect the development of ACI.