术中唤醒麻醉联合多模态影像在再次切除脑复发胶质瘤中的应用:20例患者2年随访

目的观察术中唤醒麻醉联合多模态影像在切除脑复发胶质瘤患者手术中的作用和疗效。方法回顾分析2017年1月~ 2020年12月广东药科大学附属第一医院神经外科20例再次手术切除的脑复发胶质瘤患者的临床资料，根据手术方式分为唤醒麻醉组（n=6）和常规手术组（n=14）。两组术中均根据术前功能磁共振神经影像导航引导下，通过皮层电刺激技术定位语言或运动皮层区域，在荧光显微镜下根据肿瘤荧光显影范围切除肿瘤。使用3D-slicer软件评估肿瘤切除程度；利用简易智力状况检查及Karnofsky功能状态评分比较患者术前、术后1周的认知功能和生活状态，随访1次/3月。结果20例患者的复发时间14.65± 7.64月。所有手术均顺利进行，唤醒麻醉组患者完全配合术者指令动作，术中电刺激确定语言功能区1例，运动功能区1例。术后病理均为胶质母细胞瘤，WHO Ⅳ级。根据3D-slicer软件测量，唤醒麻醉组肿瘤减负率高于常规手术组（P < 0.05）。唤醒麻醉组无术后并发症及死亡病例，常规手术组出现神经功能近期障碍者1例。常规手术组患者术后1周的简易智力状况检查评分、Karnofsky功能状态评分较术前明显降低（P < 0.05），唤醒麻醉组各指标差异无统计学意义（P > 0.05）。两组患者随访时间为3~24月，两组间无进展生存率和总生存率差异无统计学意义（P > 0.05）。结论术中唤醒麻醉结合多模态影像有助于在保护患者神经功能的前提下，最大化切除脑复发胶质瘤，为保障患者再次手术后的生活质量提供了一种安全的手术策略。 

Application of intraoperative awake anesthesia combined with multimodal images in reoperation of patients with recurrent glioma: 20 cases of two-year follow-up study

ObjectiveTo observe the effect of intraoperative awake anesthesia combined with multimodal images in the resection of recurrent glioma.MethodsThe clinical data of 20 patients with recurrent glioma who underwent reoperation in our hospital from January 2017 to December 2020 were retrospectively analyzed. They were divided into awake anesthesia group (n=6) and conventional operation group (n=14). Under the guidance of preoperative fMRI neuronavigation, the language or motor cortex was located by cortical electrical stimulation technology, and the tumor was removed under fluorescence microscope. 3D-slicer software was used to evaluate the extent of tumor resection. Mini mental state examination and Karnofsky functional state score were used to compare the cognitive function and life status of patients before and 1 week after surgery. Follow-up was conducted every 3 months.ResultsTwenty patients with recurrent gliomas were selected for reoperation, the average recurrence time was 14.65±7.64 months. There was no significant difference in preoperative baseline data between the two groups (P > 0.05). All the operations were carried out smoothly. In the awake anesthesia group, the patients fully cooperated with the operator's instructions. During the operation, 1 case of language functional area and 1 case of motor functional area were confirmed by electrical stimulation. Postoperative pathology was glioblastoma, WHO grade IV. According to 3D-slicer software measurement, the tumor burden reduction rate of awake anesthesia group was significantly higher than that of conventional operation group (P < 0.05). There were no postoperative complications and death cases in the awake anesthesia group, but 1 case of recent neurological dysfunction occurred in the conventional operation group. The Mini mental state examination and Karnofsky functional state score in the conventional operation group were significantly lower than those before operation (P < 0.05), but there was no significant difference in the awake anesthesia group (P > 0.05). Follow-up time was 3~24 months, there was no significant difference in progression free survival and overall survival between the two groups (P > 0.05).ConclusionIntraoperative awake anesthesia combined with multimodal images is helpful to maximize the resection of brain recurrent gliomas on the premise of protecting patients' neurological function, and provides a safe surgical strategy for ensuring the quality of life of patients after reoperation.