| 广州管圆线虫病嗜酸性粒细胞增高机制的实验研究进展 |
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| 引用本文： | 陈小华,刁宗礼,温艳,阴赪宏.广州管圆线虫病嗜酸性粒细胞增高机制的实验研究进展[J].中国病原生物学杂志,2008,3(9). |
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| 作者姓名： | 陈小华 刁宗礼 温艳 阴赪宏 |
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| 作者单位： | 首都医科大学附属北京友谊医院,北京热带医学研究所,北京,100050 |
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| 摘 要： | 广州管圆线虫病(angiostrongyliasis cantonensis,AC)又称嗜酸粒细胞增多性脑膜炎或脑膜脑炎(eosinophilic meningitis or meningoencephalitis.EM),IL-5、MMP-9和PAs等通过不同机制参与非正常宿主小鼠广州管圆线虫感染所引起的嗜酸性粒细胞增高及EM病理生理过程,阐明其机制可为揭示人体广州管圆线虫病的病理生理变化及发展有效治疗策略提供依据。
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| 关 键 词： | 广州管圆线虫病 嗜酸粒细胞增多症 白细胞介素5 胶原酶B 纤溶酶原激活物 综述 |
Current experimental advances on eosinophilia mechanism in angiostrongyliasis cantonensis |
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| CHEN Xiao-hua,DIAO Zong-li,WEN Yan,YIN Cheng-hong.Current experimental advances on eosinophilia mechanism in angiostrongyliasis cantonensis[J].Journal of Pathogen Biology,2008,3(9). |
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| Authors: | CHEN Xiao-hua DIAO Zong-li WEN Yan YIN Cheng-hong |
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| Abstract: | Angiostrongyliasis cantonensis(AC)can cause eosinophilia and pathophysiology progress in non-permissive hosts,such as mouse,infected wit,in which IL-5,MMP-9 and PAs have been involved.And the disease is also called e- osinophilic meningitis or meningoencephalitis(EM).Elucidating the mechanism of AC and EM can contribute to revealing pathophysiology and developing strategies for the treatment of human angiostrongyliasis. |
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| Keywords: | Angiostrongyliasis cantonensis eosinophilia IL-5 MMP9 plasminogen activators review |
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