| 急性脑梗死患者血清可溶性E-选择素、可溶性L-选择素的表达及其与脑梗死体积的关系 |
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| 引用本文： | 阎俊,周红,李继民.急性脑梗死患者血清可溶性E-选择素、可溶性L-选择素的表达及其与脑梗死体积的关系[J].临床神经病学杂志,2010,23(1). |
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| 作者姓名： | 阎俊 周红 李继民 |
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| 作者单位： | 1. 南京医科大学附属脑科医院老年神经内科,210029
2. 东南大学附属中大医院神经内科 |
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| 摘 要： | 目的 探讨急性脑梗死(ACI)患者外周血可溶性E(sE)-选择素、可溶性L(sL)-选择素表达的变化及其与脑梗死体积的关系.方法 采用酶联免疫吸附法(ELISA)测定30例ACI患者(发病＜72 h)血清sE-选择素、sL-选择素的表达水平,并与20名健康者作对照.应用MRI弥散加权成像(DWI)技术测量ACI患者急性期脑梗死的体积,分析其与血清sE-选择素及sL-选择素水平的关系.结果 ACI患者血清sE-选择素的表达水平(10.49±8.70)ng/ml]显著高于正常对照组(2.93±2.07)ng/ml](P＜0.01),而sL-选择素的表达水平(4.29±2.22)ng/ml]显著低于正常对照组(6.41±3.28)ng/ml](P＜0.01);血清sE-选择素、sL-选择素水平与脑梗死体积不相关.结论 ACI患者血清sE-选择素表达上调,sL-选择素表达下凋,但都与脑梗死体积不相关,两者可能参与了缺血性脑损伤的病理过程.
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| 关 键 词： | 急性脑梗死 可溶性E-选择素 可溶性L-选择素 |
Expression of serum soluble E-selectin and soluble L-selectin in patients with acute cerebral infraction and its correlation with infarction volume |
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| YAN Jun
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ZHOU Hong
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LI Ji-min.Expression of serum soluble E-selectin and soluble L-selectin in patients with acute cerebral infraction and its correlation with infarction volume[J].Journal of Clinical Neurology,2010,23(1). |
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| Authors: | YAN Jun ZHOU Hong LI Ji-min |
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| Institution: | YAN Jun,ZHOU Hong,LI Ji-min.Department of Geriatric Neurology,Brain Hospital Affiliated to Nanjing Medical University,Nanjing 210029,China |
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| Abstract: | Objective To investigate the expression of serum soluble E(sE)-selectin and soluble L(sL)-selectin in patients with acute cerebral infraction(ACI)and its correlation with the volume of the infarction.Methods The expression of serum sE-selectin and sL-selectin in 30 ACI patients(within 72 h after onset)were measured by ELISA,and the results were compared with 20 healthy controls.The volume of the infarction in ACI patients was measured by diffusion weighted imaging(DWI).The relationship between the infarctio... |
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| Keywords: | acute cerebral infarction soluble E-selectin soluble L-selectin |
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