| 环境雌激素双酚A对小鼠脾细胞周期的影响 |
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| 引用本文： | 杨湘山,李景舜,赵淑华,杨晓光,刘洪阳,赵力. 环境雌激素双酚A对小鼠脾细胞周期的影响[J]. 现代预防医学, 2007, 34(5): 899-900 |
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| 作者姓名： | 杨湘山 李景舜 赵淑华 杨晓光 刘洪阳 赵力 |
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| 作者单位： | 吉林大学公共卫生学院,长春,130021 |
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| 摘 要： | [目的]观察环境雌激素双酚A对小鼠脾细胞周期的的影响。[方法]每天分别以0.9mg/kg、9mg/kg、18mg/kg剂量给予小鼠腹腔注射双酚A,分别在连续染毒14d后处死小鼠,取脾,测定脾细胞周期。[结果]小鼠脾细胞G1期、G2期明显增加,而S期明显减少。[结论]双酚A可以诱导小鼠脾细胞G1、G2期阻滞,抑制脾脏细胞的分裂增殖。
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| 关 键 词： | 双酚A 脾脏 细胞周期 |
| 文章编号： | 1003-8507（2007）05-0899-02 |
| 收稿时间： | 2006-02-20 |
| 修稿时间： | 2006-02-20 |
EFFECTS OF THE ENVIORNMENTAL ESTROGEN -BPA ON THE CELL CYCLE OF MICE SPLEEN |
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| YANG Xiang-shan, LI Jing-shun, ZHAO Shu-hua,et al.. EFFECTS OF THE ENVIORNMENTAL ESTROGEN -BPA ON THE CELL CYCLE OF MICE SPLEEN[J]. Modern Preventive Medicine, 2007, 34(5): 899-900 |
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| Authors: | YANG Xiang-shan LI Jing-shun ZHAO Shu-hua et al. |
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| Affiliation: | School of Public Health, Jilin University, Changchun 130021, China |
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| Abstract: | [Objective]To observe the effects of the Environmental Estrogen-BPA on the cell cycle of Mice spleen and study the injury action of Bisphenol A to the mice spleen.[Methods]Cell cycle were detected in spleen with flow cytometry(FCM).The high,medium and low dose of Bisphenol A were injected into the mice belly cavity once everyday.The mice after Bisphenol A was injected 14 days were executed,taking the spleen cell and measuresing the cell cycle.[Results]It was found that G1 and G2 phases of spleen cells increased significantly,whereas S phase cells were decreased at the same time.[Conclusion]BPA can arrest G1 and G2 Phases,inhabit the division and multiplication of spleen cellsa. |
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| Keywords: | Bisphenol A Spleen Cell cycle |
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